Changes in the ubiquitination system in children with cerebral palsy

Authors : Ayşe Gülşen DOĞAN, İhsan ÇETİN
Pages : 652-656
Doi:10.16899/jcm.1296330
View : 88 | Download : 97
Publication Date : 2023-07-31
Article Type : Research Paper
Abstract :Objective: We aimed to investigate the levels of Ubiquitin Carboxy Terminal Hydrolase-L1 enzyme insert ignore into journalissuearticles values(UHC-L1);, Transactive Response DNA Binding Protein-43 insert ignore into journalissuearticles values(TDP-43); and Cullin-3 in peripheral blood associated with ubiquitination processes in children with cerebral palsy insert ignore into journalissuearticles values(CP);. Materials and Methods: We included 50 children with CP in the first patient group. In the control group, there were 30 healthy children who were matched with the patient groups in terms of age and gender. We also recorded risk factors for CP, CP type, botox application, orthosis use, maternal age at birth, and additional problems. Patients aged 6-10 years, diagnosed with CP, without genetic, metabolic disease or mental retardation history were included in this study. Results: There were 32 female and 18 male patients in the CP group, while there were 19 female and 11 male volunteers in the control group. Maternal age was significantly higher in the CP group insert ignore into journalissuearticles values(p=0.002);. In our study, as a result of the comparison between the control group and the CP group in terms of UCH-L1, TDP-43 and Cullin 3 levels; the levels of UCH-L1 insert ignore into journalissuearticles values(p=0.048);, TDP-43 insert ignore into journalissuearticles values(p=0.028); and Cullin 3 insert ignore into journalissuearticles values(p=0.042); in the CP group were found to be statistically significantly lower than the levels of the control group. Conclusion: The low serum concentrations of UCHL-L1, Cullin 3 and TDP-43 molecules in the CP group and the statistically positive correlation of these molecules with each other may help to understand the neuronal pathophysiology after disruption of the ubiquitination system.
Keywords : Ubiquitin Karboksi Terminal Hidrolaz L1 enzimi, Transaktif Yanıt DNA Bağlayıcı Protein 43, Cullin 3, serebral palsi

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