THE ASSOCIATION BETWEEN SERUM SOLUBLE KLOTHO LEVEL AND CARDIOVASCULAR DİSEASE AND MORTALİTY IN ROUTİNE HEMODIALYSIS PATIENTS

Authors : Edip Erkuş, Ibrahim Güney, Zafer Büyükterzi

Pages : 1033-1038

View : 166 | Download : 141

Publication Date : 2023-11-30

Article Type : Research Paper

Abstract :Aim: Serum sKlotho plays a role in identifying the risk of cardiovascular disease or death in some human populations and animal experiments. In this study, the relationship between sKlotho levels and echocardiographic parameters after 18 months of follow-up and mortality at 30 months of follow-up in routine hemodialysis patients was investigated. Matarial and Method: Groups of patients with different sKlotho rates (≥1.24 ng/ml and <1.24 ng/ml) and ages (<54 years and ≥54 years) were compared. Results: No significant difference was found between the left ventricular mass index and left ventricular mass parameters calculated between the sKlotho <1.24 and ≥1.24 groups. No significant difference was found between the left ventricular mass index and left ventricular mass parameters calculated between the two different age (<54 years and ≥54 years) groups. In order to determine the association between sklotho and all-reason mortality in 136 patients followed for 30 months, two groups of 34 patients who died and 102 patients who survived were compared. A significant difference was observed between these two groups in terms of age, entry creatinine, sodium bicarbonate, C-reactive protein, albumin level and existence of Diabetes Mellitus. Although there was no considerable distinction in the two groups with regards to sklotho values, the sklotho level was found to be lower in the deceased group. Conclusion: We think that sKlotho is not an appropriate indicator to predict uremic cardiomyopathy in the long term, but sKlotho levels may be useful in predicting mortality in studies with larger patient populations.
Keywords : Kardiyomiyopati, Hemodiyaliz, sKlotho

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