Relationship Between Blood Gas and NT-ProBNP in Patients Presenting with Dyspnea

Authors : Semahat Karahisar Şirali, Muhammed Emir İnce

Pages : 126-131

View : 41 | Download : 58

Publication Date : 2025-05-31

Article Type : Research Paper

Abstract :Background: Dyspnea can be caused by different systems, and the negative predictive value of N_terminal pro-brain natriuretic peptide (NT-proBNP) is indicative of heart failure. We aimed to evaluate the relationship between blood gases and NT-proBNP in patients presenting with dyspnea and to determine the guiding factors in the differential diagnosis. Methods: Patients admitted to our hospital with dyspnea and who underwent NT-proBNP and venous blood gas tests at the same time were included in the study. Demographic data, comorbidities, and laboratory data were recorded. The relationship between NT-proBNP and venous blood gas parameters was evaluated. p<0.05 was considered significant. Results: The mean age of the 523 patients was 74±12.83 years, with 50.3% of the patient population identified as male. In the total group, NT-proBNP demonstrated a positive correlation with age (p < 0.001) and a negative correlation with current bicarbonate (cHCO3) (p < 0.001), standard bicarbonate (HCO3) (p < 0.001), pCO2 (p = 0.022), and BE (p < 0.001). In patients with chronic kidney disease (CKD), NT-proBNP demonstrated a moderately negative correlation with cHCO3 (p = 0.008), HCO3 (p = 0.019), and BE (p = 0.010). In patients with heart failure (HF), there was a moderate negative association between NT-proBNP and cHCO3 (p = 0.002), HCO3 (p = 0.001), and BE (p = 0.001). Conclusion: In the absence of definitive evidence of heart failure in a dyspneic patient, it is reasonable to consider the potential contribution of impaired renal function to the overall evaluation.
Keywords : Nt-proBNP, venöz kan gazı, kalp yetmezliği

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