Evaluation of Demographic, Clinical and Laboratory Parameters and Long-Term Renal Effects in Infants with Hypernatremic Dehydration

Authors : Saime Sündüs Uygun

Pages : 121-125

View : 34 | Download : 46

Publication Date : 2025-05-31

Article Type : Research Paper

Abstract :Aim: Neonatal hypernatremic dehydration is a potentially life-threatening condition in infants, primarily caused by inadequate breast milk intake. This study aimed to evaluate the demographic characteristics, clinical and laboratory findings, and risk factors in term neonates diagnosed with neonatal hypernatremic dehydration, as well as to assess its long-term impact on renal function. Methods: This retrospective study included 36 term neonates diagnosed with Neonatal hypernatremic dehydration and followed in our clinic between January 2014 and December 2019. Data on demographics, clinical presentation, dehydration severity, laboratory values at admission, and serum creatinine and urea levels at follow-up (1–5 years later) were recorded. Dehydration was classified based on percentage of weight loss. Statistical analyses included Spearman correlation and ROC analysis to evaluate the relationship between hypernatremia and renal function. Results: Of the 36 patients, 52.7% were male and 72.2% were delivered vaginally. Feeding difficulties (58%) and jaundice were the most common presenting complaints. Sixteen infants had >10% weight loss and were classified as moderately or severely dehydrated. Serum creatinine levels at admission were ≥0.6 mg/dL in 83% and ≥1.0 mg/dL in 28% of cases, suggesting significant renal involvement. At follow-up, creatinine levels normalized in all patients. The lack of urine output data was a limitation. Conclusion: Neonatal hypernatremic dehydration is a serious but preventable condition. Risk is higher in infants born to primiparous mothers or by cesarean section. Early breastfeeding support, maternal education, and post-discharge follow-up are critical for prevention and early detection of potential renal complications.
Keywords : Hipernatremik Dehidratasyon, emzirme güçlükleri, renal hasar

ORIGINAL ARTICLE URL