Adenosine deaminase and Guanase deaminase activities in serum of patients with rheumatoid Arthritis

Authors : Suleyman ONAL

Pages : 215-219

View : 13 | Download : 7

Publication Date : 2013-08-14

Article Type : Research Paper

Abstract :We investigated purin and primidin salvage pathways in rheumatoid arthritis insert ignore into journalissuearticles values(RA);. For the aim, Adenosine deaminase insert ignore into journalissuearticles values(AD); and Guanosine deaminase insert ignore into journalissuearticles values(GD); activities in serum of patients with di!erent manifestations of the disease insert ignore into journalissuearticles values(n=32); were investigated and compared with the control group of healthy individuals insert ignore into journalissuearticles values(n=52);. RA cases were classified with respect to their clinics and treatment. The ADA activities were significantly higher insert ignore into journalissuearticles values(p<0.01); in patients with RA than in control although GD activity levels were found to be lower insert ignore into journalissuearticles values(p<0.01);. When compared their AD and GD levels amongst the classified RA groups, there was no di!erence in AD levels amongst cases. In conclusion, increased serum AD activities in patients with RA may be dependent on and reflect the increase in phagocytic activity of macrophages and maturation of T-lymphocytes. The results indicated that plasma AD and GA activity can be used for the diagnosis of RA disease to support clinical findings and as an index for disease.
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