Is Hypericum perforatum agonist or antagonist of TRPC6 in neurons?

Home Page
About
Submit A Journal
Submit A Conference
Submit Paper/Book
- Submit a Preprint
- Submit a Book
Contact

Journal of Cellular Neuroscience and Oxidative Stress
Volume:8 Issue:2
Is Hypericum perforatum agonist or antagonist of TRPC6 in neurons?

Is Hypericum perforatum agonist or antagonist of TRPC6 in neurons?

Pages : 595-600

View : 44 | Download : 11

Publication Date : 2016-12-31

Article Type : Review Paper

Abstract :Transient receptor potential canonical 6 insert ignore into journalissuearticles values(TRPC6); channel is a family of transient receptor superfamily. Hyperforin is an active component of Hypericum species including Hypericum perforatum insert ignore into journalissuearticles values(HPer);. In the review paper, t he author summarizes the recent information between TRPC6-induced Ca 2+ entry, HPer and hyperforin to understand the etiology of the neurological diseases and potential therapeutic strategies . The TRPC6 in several cell types is activated by 2-Aminoethoxydiphenylborane insert ignore into journalissuearticles values(2-APB);, 4,5 triphosphate insert ignore into journalissuearticles values(IP 3 ); and diacylglycerol insert ignore into journalissuearticles values(DAG); pathways, although it was inhibited in the cells by several non-specific antagonists including gadolinium and lanthanum. Results of limited studies indicated that hyperforin caused intracellular Ca 2+ elevations through TRPC6 activation in neurons and cells , although the intracellular Ca 2+ elevation results were not confirmed by many recent studies. Release Ca 2+ from internal stores instead of extracellular Ca 2+ entry through activation of TRPC6 channel in neurons of brain was also reported. The TRPC6-induced Ca 2+ influx was inhibited in brain by active components of some antioxidants. In conclusion, the present literature information shows that interaction between TRPC6-induced Ca 2+ entry and hyperforin in neurons and cell lines are too complex and it has not been clarified yet.
Keywords : TRPC6, Hypericum perforatum, Hyperforin, Calcium ion

ORIGINAL ARTICLE URL

* There may have been changes in the journal, article,conference, book, preprint etc. informations. Therefore, it would be appropriate to follow the information on the official page of the source. The information here is shared for informational purposes. IAD is not responsible for incorrect or missing information.