Single Dose Metformin-Induced Severe Metabolic Acidosis

Authors : Kemal Şener, İnan Beydilli, Tamer Çolak, Adem Çakır, Giray Altunok, Raşit Baysal, Ertuğrul Altuğ

Pages : 70-73

Doi:10.33706/jemcr.1628492

View : 49 | Download : 21

Publication Date : 2025-06-29

Article Type : Other Papers

Abstract :Introduction: Metformin, a member of the biguanide family, is one of the most widely used drugs in the treatment of diabetes worldwide. It was first commercialized in 1957, and its use has steadily increased since then. Metformin is recommended as the first pharmacological agent in the treatment of type 2 diabetes. Case Report: 29-year-old female patient presented to our emergency department due to nausea and vomiting. In her history, she denied diarrhea, urinary symptoms suggestive of urinary tract infection, ingestion of any unusual food, use of any other medications or substances, and reported spending the entire day at home. Upon presentation, the patient was in good general condition, awake, alert, and cooperative. Later the same day (approximately 8 hours later), the patient was brought back to the emergency department via emergency medical services with decreased level of consciousness. Paramedics reported administering 50 mg intravenous dextrose due to a blood sugar level of 30 mg/dL. Conclusion: Recently, metformin has been used for weight loss as well as for therapeutic purposes. It is seen that even a single dose of metformin can cause serious side effects. People who use metformin both within and outside the indication should be careful.
Keywords : Laktik asidoz, Metformin, Tek Doz, MALA

ORIGINAL ARTICLE URL