Small Round Blue Cell Sarcoma of the Left Humerus in a Pregnant Patient: Clinical Course of a Rare Aggressive Soft Tissue Tumor

Authors : Omer Esmez, Gülnihal Deniz

Pages : 105-107

Doi:10.33706/jemcr.1673715

View : 60 | Download : 35

Publication Date : 2025-09-30

Article Type : Other Papers

Abstract :Introduction: Small round blue cell tumors (SRBCT) represent a heterogeneous group of aggressive tumors with overlapping histological features, often requiring complex immunohistochemical and molecular studies for accurate diagnosis. Their occurrence during pregnancy poses significant diagnostic and therapeutic challenges, particularly when located in rare anatomical sites such as the humerus. Case Report: We present the case of a 21-year-old pregnant woman at 31 weeks of gestation who was admitted with progressive pain and swelling in the left upper extremity. MRI revealed a large, intramedullary soft tissue mass in the mid-diaphysis of the left humerus with extension to adjacent musculature and neurovascular structures. Initial histopathological evaluation identified a poorly differentiated SRBCT. Despite extensive immunohistochemical work-up, a definitive diagnosis, necessitating advanced molecular analysis, remained elusive. The patient underwent cesarean delivery at 33 weeks due to obstetric indications. Subsequent PET-CT imaging demonstrated multiple hypermetabolic lesions consistent with metastatic disease. Chemotherapy with the VAC regimen was initiated following postpartum stabilization. Conclusion: This case underscores the complexity of diagnosing SRBCT during pregnancy and highlights the importance of multidisciplinary collaboration. Early recognition, thorough histopathological and molecular evaluation, and individualized oncologic and obstetric management are critical for optimizing maternal and fetal outcomes.
Keywords : Küçük Yuvarlak Mavi Hücreli Tümör, Gebelik, Humerus, Yumuşak Doku Sarkomu, Perinatal Onkoloji

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