Evaluation of the hematologic indices in patients with thyrotoxicosis with distinct etiologies: a case-control study

Authors : Ece ÇETİN, Fatih KAMIŞ, Ersen KARAKILIÇ, Mehmet ARSLAN, Yavuz BEYAZIT

Pages : 198-202

Doi:10.32322/jhsm.857780

View : 26 | Download : 14

Publication Date : 2021-03-28

Article Type : Research Paper

Abstract :Aim: Thyrotoxicosis is a clinical state of inappropriately high levels of free T4 insert ignore into journalissuearticles values(thyroxine); and/or free T3 insert ignore into journalissuearticles values(tri-iodothyronine); in the body caused by distinct etiologies including Graves’ disease insert ignore into journalissuearticles values(GD);, subacute thyroiditis insert ignore into journalissuearticles values(SAT);, toxic adenoma and toxic multinodular goiter insert ignore into journalissuearticles values(TMNG);. Simple hematologic indices such as neutrophil/lymphocyte ratio insert ignore into journalissuearticles values(NLR);, and platelet/lymphocyte ratio insert ignore into journalissuearticles values(PLR); and mean platelet volume insert ignore into journalissuearticles values(MPV); have increasingly been mentioned as measures of presence and severity of thyrotoxicosis. In this study, we aimed to analyze whether there is a link between these peripheral blood parameters and the presence of thyrotoxicosis. Material and Methods: A total of 46 GD, 46 TMNG, 39 TA and 45 SAT patients and 45 control subjects were studied. Laboratory parameters in all patients were recorded and NLR, PLR and MPV values were recorded from peripheral blood complete blood cell counts. Results: This study showed that NLR and PLR levels are elevated in patients with SAT in comparison with other thyrotoxic patient groups and controls. The post hoc analysis of comparison of NLR and PLR in each study groups revealed that NLR and PLR were statistically different in the SAT group in comparison to the GD, TMNG, TA, and healthy controls. A significant decrease in the level of MPV was demonstrated in thyrotoxicosis patients insert ignore into journalissuearticles values(p<0.000);. Conclusion: NLR, PLR and MPV that is routinely and automatically calculated from complete blood count plays an important diagnostic role in thyrotoxicosis
Keywords : Thyrotoxicosis, mean platelet volume, neutrophil to lymphocyte ratio, platelet to lymphocyte ratio