Does red ginseng ameliorate liver damage caused by obstructive jaundice? : an experimental study

Authors : Abdullah DURHAN, Koray KOŞMAZ, Abdullah ŞENLİKCİ, Ender ERGÜDER, Marlen SÜLEYMAN, Mehmet Esat DUYMUŞ, Yusuf Murat BAĞ, Mevlüt Recep PEKCİCİ, Mehmet ŞENEŞ, İlknur ALKAN KUŞABBİ, Eylem Pınar ESER, Sema HÜCÜMENOĞLU

Pages : 233-239

Doi:10.32322/jhsm.900023

View : 25 | Download : 10

Publication Date : 2021-03-28

Article Type : Research Paper

Abstract :Aim: This experimental study aimed to evaluate the hepatoprotective effect on obstructive jaundice insert ignore into journalissuearticles values(OJ); of oral red ginseng insert ignore into journalissuearticles values(RG); extract, which is known to have anti-inflammatory and antioxidant properties. Methods: The rats were randomly separated into 3 groups of 10 rats: the sham group, the control group, and the treatment group. In Group 1 insert ignore into journalissuearticles values(sham);, the common bile duct insert ignore into journalissuearticles values(CBD); was identified but no ligation or transection was performed. In Group 2 insert ignore into journalissuearticles values(control);, the CBD was identified and ligation and transection were performed, but no treatment was given. In Group 3 insert ignore into journalissuearticles values(RG group);, CBD ligation and transection were performed, then RG extract was administered via an orogastric tube at a dose of 100 mg/ kg/day for 10 days. After 10 days, blood samples were taken for biochemical analysis, and liver tissue samples for biochemical and histopathological analysis. Results: Significantly higher serum albumin levels and lower serum alanine aminotransferase insert ignore into journalissuearticles values(ALT); and aspartate aminotransferase insert ignore into journalissuearticles values(AST); levels were determined in the RG group than in the control group insert ignore into journalissuearticles values(p = 0.028, p = 0.001 and p = 0.034, respectively);. In the oxidative stress parameters, malondialdehyde insert ignore into journalissuearticles values(MDA); levels and catalase insert ignore into journalissuearticles values(CAT); levels were significantly different between the RG group and control group insert ignore into journalissuearticles values(p = <0.001 for each);. Total sulfhydryl insert ignore into journalissuearticles values(T-SH); was not at a statistically significant level, although it was high and approached the value of the sham group insert ignore into journalissuearticles values( p = 0.076);. In the histopathological evaluation, the RG group had statistically significantly lower scores in all parameters compared to the control group insert ignore into journalissuearticles values(p<0.05);. Conclusion: The results of this study showed that RG has a strong hepatoprotective effect as a result of its anti-inflammatory and antioxidant properties.
Keywords : Red ginseng, obstructive jaundice, anti inflammatory properties, antioxidant properties, hepatoprotective effects