The relationship between sarcopenia and nesfatin-1 and ghrelin levels in patients with chronic obstructive pulmonary disease

Authors : Gülay DAŞDEMİR İLKHAN, Selay ARSLAN, Yücel ARMAN, Özgür ALTUN, Hakan CELİKHİSAR, Tufan TÜKEK

Pages : 402-407

Doi:10.32322/jhsm.896660

View : 27 | Download : 11

Publication Date : 2021-07-15

Article Type : Research Paper

Abstract :Background and Aim: In this study, we aimed to investigate the relationship between the levels of adipocytokines anorexigenic nesfatin-1 and orexigenic ghrelin levels and body mass index insert ignore into journalissuearticles values(BMI);, muscle mass, muscle strength and sarcopenia in patients with chronic obstructive pulmonary disease insert ignore into journalissuearticles values(COPD);. Material and Method: The patients were divided into two groups according to the severity of COPD. Body mass index insert ignore into journalissuearticles values(BMI);, body fat and muscle measurements were measured with bioelectrical impedance device. A hand-grip strength test was performed with a hand dynamometer to determine muscle strength. We used the mMRC insert ignore into journalissuearticles values(Modified Medical Research Council Questionnaire); questionnaire to measure the intensity of dyspnea during daily activities. A 6-minute walk test insert ignore into journalissuearticles values(6MWT); was used to test functional capacity and physical exercise tolerance. COPD Assessment Test insert ignore into journalissuearticles values(CAT); was performed to determine the health status. Serum nesfatin-1 and ghrelin levels were measured in all patients. Results: In a total of 90 patients insert ignore into journalissuearticles values(16 female and 74 male); were included in the study prospectively. There was not any significant difference regarding the Nesfatin-1, ghrelin and Nesfatin-1/ghrelin ratio between mild/moderate or severe COPD patients. Muscle strength was correlated positively with 6MWT, nesfatin-1 and ghrelin levels, but negatively correlated with CAT score and mMRC score. The number of patients in the advanced stage of COPD was higher in the sarcopenia group than in the non-sarcopenia group. Conclusion: There was a positive correlation between muscle strength and nesfatin-1 and ghrelin levels. However, muscle strength was negatively correlated with mMRC and CAT scores. Approximately 19% of COPD patients had sarcopenia. Serum nesfatin-1 and ghrelin levels were not different between sarcopenic and non-sarcopenic COPD patients.
Keywords : Chronic obstructive pulmonary disease, ghrelin, nesfatin 1, sarcopenia