Cardiovascular risk factors in polycystic ovary syndrome; the relationship of dyslipidemia and obesity

Authors : Şefik GÖKÇE, Dilşad HERKİLOĞLU

Pages : 526-531

Doi:10.32322/jhsm.901791

View : 28 | Download : 10

Publication Date : 2021-09-05

Article Type : Research Paper

Abstract :Aim: The abnormal endocrinological picture that occurs in polycystic ovary syndrome insert ignore into journalissuearticles values(PCOS); has been shown to affect many systems and can lead to a wide variety of complications. In our study, it was aimed to examine hormone levels, obesity, serum lipid levels and hematological parameters in adult women with PCOS. Material and Methods: The present study included 62 patients diagnosed with PCOS and 45 healthy women. Demographic data and laboratory results of all women were collected them from hospital automation system records and were analyzed. Results: The mean body mass index insert ignore into journalissuearticles values(BMI); insert ignore into journalissuearticles values(p=0.041);, total cholesterol insert ignore into journalissuearticles values(p=0.038);, triglyceride insert ignore into journalissuearticles values(p=0.022); and very low density lipoprotein insert ignore into journalissuearticles values(VLDL); cholesterol insert ignore into journalissuearticles values(p=0.003); levels in the patient group were significantly higher than the control group. In the patient group, anti-Müllerian hormon insert ignore into journalissuearticles values(AMH); insert ignore into journalissuearticles values(p<0.001);, total testosterone insert ignore into journalissuearticles values(p<0.001); and free testosterone insert ignore into journalissuearticles values(p<0.001); were significantly higher than the control group, and follicle-stimulating hormon insert ignore into journalissuearticles values(FSH); was significantly lower insert ignore into journalissuearticles values(p<0.001);. The rate of women insert ignore into journalissuearticles values(57.6%); with BMI value ≥25 kg/m2 in the patient group was significantly higher than the control group insert ignore into journalissuearticles values(35.6%); insert ignore into journalissuearticles values(p=0.026);. In addition, having a BMI value of ≥25 kg/m2 had 2.47-fold insert ignore into journalissuearticles values(odds ratio; 1.11-5.48); higher risk for PCOS development. Conclusion: In our study, it was concluded that obesity plays a role in the development of PCOS, that the level of AMH in PCOS patients increases significantly enough to gain a diagnostic value, that a significant dyslipidemia develops in PCOS, and this might be a risk for the development of cardiovascular disease in the future.
Keywords : Polycystic ovarian syndrome PCOS, anti Mullerian hormone, body mass index, dyslipidemia, cholesterol