Evaluation of the diagnostic efficiency of systemic immune-inflammation index in prostate biopsy

Authors : Mehmet DEMİR, İsmail YAĞMUR, Eyyup Sabri PELİT, Bülent KATI, İbrahim Halil ALBAYRAK, Halil ÇİFTÇİ

Pages : 897-900

Doi:10.32322/jhsm.981394

View : 36 | Download : 13

Publication Date : 2021-09-24

Article Type : Research Paper

Abstract :Aim: This study aimed to evaluate the diagnostic efficacy of systemic immune-inflammation index insert ignore into journalissuearticles values(SII); in patients with prostate cancer insert ignore into journalissuearticles values(PCa); who have undergone prostate biopsy and have a prostate-specific antigen insert ignore into journalissuearticles values(PSA); value of 4–10 ng/ml. Material and Method: In this study we included patients with a PSA value of 4–10 ng/mL, who underwent transrectal ultrasound-guided 12-core prostate biopsy between January 2010 and March 2021. The patients were divided into two groups as those with and without cancer. Those with cancer were divided into two groups as low grade insert ignore into journalissuearticles values(grade 1 and 2); and high grade insert ignore into journalissuearticles values(grade 3–5); according to the International Society of Urologic Pathologists insert ignore into journalissuearticles values(ISUP); grades. PSA, neutrophil-lymphocyte ratio insert ignore into journalissuearticles values(NLR);, prostate volume, platelet-to-lymphocyte ratio insert ignore into journalissuearticles values(PLR); and SII were compared between the groups. Results: The mean age of the 182 patients included in the study was 63.4±8.0 years, and the mean PSA value was 6.69±2.45 ng/mL. Benign prostate disease were detected in 142 insert ignore into journalissuearticles values(78%); of the patients and PCa in 40 insert ignore into journalissuearticles values(22%); patients. PSA, PLR, NLR and SII did not differ in those with cancer. Low ISUP grade cancer was detected in 80% of the patients and high ISUP grade cancer in 20%. PSA and PLR values were significantly higher in patients with high ISUP grade PCa compared to those with low ISUP grade insert ignore into journalissuearticles values(p < 0.05);. There was no difference in SII values between the two groups. PSA, PLR and SII values of patients with high ISUP grade PCa were significantly higher than those without cancer insert ignore into journalissuearticles values(p<0.05);. Conclusions: SII and PLR, which can be easily calculated from peripheral blood, can be an effective predictor of pre-biopsy high-grade ISUP PCa.
Keywords : prostate cancer, diagnosis, systemic immune inflammation index, platelet to lymphocyteratio, biopsy