Effects of contrast medium exposure on urine albumin/creatinine ratio

Authors : Sanem KAYHAN, Fatih KİVRAKOGLU, Aysenur Miray YARLIOGLU, Mercan TAŞTEMUR, İbrahim AKDAĞ

Pages : 49-53

Doi:10.32322/jhsm.1003314

View : 32 | Download : 13

Publication Date : 2022-01-17

Article Type : Research Paper

Abstract :Aim: Albuminuria is a direct consequence of renal glomerular injury and increases with glomerular dysfunction. Spot urine albumin/creatinine insert ignore into journalissuearticles values(Alb/Cr); ratio is a reasonable surrogate for 24-hour urine albumin excretion rate and certainly not without limitations. It is known that renal function can be affected following contrast agent administration. The aim of our study is to assess the changes in Alb/Cr ratio in spot urine before and after contrast agents in patients undergoing computed tomography insert ignore into journalissuearticles values(CT); scanning. Material and Method: The present study included 103 hospitalized patients aged between 18 and 75 years, who underwent contrast-enhanced CT scanning for any reason and did not develop contrast-induced nephropathy insert ignore into journalissuearticles values(CIN);. We compared the values of Alb/Cr ratio at the 6th, 12th, 24th, 48th, and 72nd hours after the procedure insert ignore into journalissuearticles values(post-procedure time); with the values at pre-procedure time. Results: The median age of the patients were 61 years. It has been observed that there is no significant increased in microalbuminuria after the use of contrast media. When the patients were evaluated for the albuminuria level before the procedure, it has been seen that 73 patients insert ignore into journalissuearticles values(70.9%); had an Alb/Cr ratio of <30 mg/g insert ignore into journalissuearticles values(group-1); and 30 patients insert ignore into journalissuearticles values(29.1%); had an Alb/Cr ratio of ≥30 mg/g insert ignore into journalissuearticles values(group-2);. In group 1, it has been observed that the Alb/Cr ratios at the post-procedure 6th, 12th, 24th, and 48th hours were statistically significantly higher than the value at pre-procedure time. In group 2, it has been observed that Alb/Cr ratio values at all post-procedure time except the 24th hour were statistically significantly lower than the values at the pre-procedure time. Conclusion: It should be considered that there might be changes in Alb/Cr ratio even without developing significant complications such as CIN in patients exposed to contrast medium.
Keywords : Contrast medium, urine albumin creatinine ratio, microalbuminuria