The correlations between pulmonary function tests and polysomnographic parameters in overlap syndrome

Authors : Sezgi ŞAHİN DUYAR, Deniz ÇELİK, Selma FIRAT

Pages : 73-78

Doi:10.32322/jhsm.1009893

View : 23 | Download : 9

Publication Date : 2022-01-17

Article Type : Research Paper

Abstract :Aim: This study aims to reveal the relationship between Pulmonary Function Tests insert ignore into journalissuearticles values(PFTs); parameters and polysomnographic parameters. It aims to determine the guiding values in treatment selection, with the hypothesis that easily accessible PFTs parameters can be useful in clinical evaluation for patients with restrictive or obstructive type disorders. Material and Method: One hundred and forty-six patients with obstructive and/or restrictive pulmonary dysfunction who underwent polysomnography in the sleep clinic of our hospital between June 2019 and December 2019 were included in the study. Polysomnography insert ignore into journalissuearticles values(PSG); parameters and PFTs results were obtained. Age, gender, body mass index insert ignore into journalissuearticles values(BMI);, Epworth Sleepiness Scale insert ignore into journalissuearticles values(ESS); score, PFTs parameters, apnea-hypopnea index insert ignore into journalissuearticles values(AHI);, nocturnal oxygen saturation, tolerable positive airway therapy modality, and pressures were recorded. Results: Of 146 patients 34.9% were women and most insert ignore into journalissuearticles values(92.5%); had an obstructive disorder in PFTs. Of the patients with the obstructive disorder, 71 were being followed up with a diagnosis of chronic obstructive pulmonary disease insert ignore into journalissuearticles values(COPD); and 64 with a diagnosis of asthma. Interstitial lung disease was observed in 5 out of 11 cases insert ignore into journalissuearticles values(7.5%); with restrictive type disorder, and obesity resulted in restrictive disorder for the remaining 6 cases. Simple snoring was observed in 5.5%. Mild OSAS was observed at a rate of 30.1%. Moderate-severe OSAS was detected in 64.4% of the patients. When the relationship between optimal inspiratory/ expiratory positive airway pressure insert ignore into journalissuearticles values(IPAP/EPAP); values determined by automatic bilevel positive airway pressure insert ignore into journalissuearticles values(ABPAP); titration and PFTs parameters were analyzed, a moderate negative correlation was observed between IPAP value and forced vital capacity insert ignore into journalissuearticles values(FVC); insert ignore into journalissuearticles values(L); insert ignore into journalissuearticles values(r=-0.432, p=0035); Discussion: The results of this study show that PFTs parameters can be used to predict polysomnographic findings for patients with obstructive/restrictive disorders. Almost two-thirds of the patients with obstructive sleep apnea insert ignore into journalissuearticles values(OSA);-related symptoms in this group were observed to have moderate-severe obstructive sleep apnea syndrome insert ignore into journalissuearticles values(OSAS);. Based on our results in ROC analysis, we believe that it would be appropriate to recommend titration with bilevel devices, especially for patients with forced expiratory volume in one second insert ignore into journalissuearticles values(FEV1);<60% and maximum expiratory flow between 25% and 75% of FVC insert ignore into journalissuearticles values(MEF25-75);<30%. Bilevel devices may be useful for patients with reduced MEF25-75 insert ignore into journalissuearticles values(representing peripheral airways);, through alveolar recruitment and pressure support. Conclusion: In our study, we demonstrated that the optimal IPAP value for treatment had a positive correlation with the oxygen desaturation index insert ignore into journalissuearticles values(ODI); and AHI and a negative correlation with minimum finger pulse oximetry insert ignore into journalissuearticles values(SpO2);, as well as a negative correlation with FVC value. Simple spirometric data along with polysomnographic data can also be helpful when determining baseline pressures in bilevel positive airway pressure insert ignore into journalissuearticles values(BPAP); titration for OSAS patients with respiratory dysfunction.
Keywords : PFTs, FVC, AHI, OSAS, IPAP