Association between vitamin D levels and frequency of disease exacerbations and hospitalizations in patients with COPD

Authors : Sertan BULUT, Harun KARAMANLI, Mustafa Engin ŞAHİN, Deniz ÇELİK, Çiğdem BİBER

Pages : 471-477

Doi:10.32322/jhsm.1050722

View : 26 | Download : 12

Publication Date : 2022-03-15

Article Type : Research Paper

Abstract :Introduction: Chronic obstructive pulmonary disease insert ignore into journalissuearticles values(COPD); is a debilitating disorder that restricts the physical activity of patients who are deprived of sunlight, which is a source of vitamin D. The purpose of this study was to assess the relationship between vitamin D and the frequency of exacerbation and hospitalization among patients with COPD. Material and Method: In the main analysis, 303 patients with COPD insert ignore into journalissuearticles values(stage GOLD A to D); were included in a retrospective cohort study in Turkey. Serum levels of vitamin D insert ignore into journalissuearticles values(25-hydroxyvitamin D); were measured in 303 patients with COPD and were associated with pulmonary function, AECOPD frequency and hospitalization in the previous year. Results: For COPD patients, the mean reference level of 25 hydroxyvitamin D in serum was 12.5 ng/dL. In comparison to patients with a serious 25-hydroxyvitamin D deficiency insert ignore into journalissuearticles values( 30 ng/dL, n=34 [11,2%]);, the risk was lower but not significant insert ignore into journalissuearticles values(incidence ratio, 0.7 [95% CI, 0.2-1.2]. In COPD patients, 25-hydroxyvitamin D rates are low correlated with 1-s forced expiratory volume insert ignore into journalissuearticles values(FEV1); insert ignore into journalissuearticles values(r=0.187, p=0.0013);. Conclusion: 25-hydroxyvitamin D deficiency is a frequent occurrence in COPD and is correlated with the frequency of exacerbation and hospitalization in COPD patients.
Keywords : Vitamin D, COPD, COPD exacerbation