Vitamin D levels and in-hospital mortality of COVID-19

Authors : Emre Sedar SAYGILI, Ersen KARAKILIÇ

Pages : 457-461

Doi:10.32322/jhsm.1056650

View : 19 | Download : 11

Publication Date : 2022-03-15

Article Type : Research Paper

Abstract :Introduction: Vitamin D deficiency may be linked to an increased susceptibility risk of COVID-19. However, the data on the link between vitamin D levels and COVID-19 related in-hospital mortality is debatable. This study investigated whether vitamin D levels are associated with intensive care unit insert ignore into journalissuearticles values(ICU); admission and COVID-19 related in-hospital mortality. Material and Method: We conducted a retrospective study with hospitalized COVID-19 patients between March 2020 and March 2021. 25 OH Vitamin D insert ignore into journalissuearticles values(Vit-D); levels <12 ng/mL were accepted as Vit-D deficiency. The patients were evaluated in two groups as Vit-D deficient and Non-Vit-D deficient. Groups were matched 1:1 by propensity score matching insert ignore into journalissuearticles values(PSM); regarding age and gender. Results: A total of 192 patients, 52.6% insert ignore into journalissuearticles values(101); of whom were female, with a median age of 71 insert ignore into journalissuearticles values(IQR:61-78);, were included in the study. Before PSM analysis, the Vit-D deficient group patients were older, female predominant, have more mortality rates. After PSM, 122 cases insert ignore into journalissuearticles values(61 cases for each group); remained, and mortality between Vit-D groups was statistically similar insert ignore into journalissuearticles values(34% vs. 26%, p=0.32);. In the univariate logistics regression analysis before PSM, Vit-D level was a significant for mortality insert ignore into journalissuearticles values(OR:0.972 CI:0.945-0.999, p=0.044);; after PSM statistical significance was lost insert ignore into journalissuearticles values(OR:0.96 CI:0.934-1.005, p=0.087);. ICU admission rates were similar between groups. Conclusion: Although mortality was higher in the group with Vit-D deficiency in the first analysis, it lost its significance on mortality after adjusting groups for age and gender. There was no relationship between vitamin D deficiency and COVID-19 in-hospital mortality.
Keywords : Vitamin D, COVID 19, Mortality, Critical Care, Hospitalization