The diagnostic value of calcium binding protein S100A8/A9 and S100A12 in acute pancreatitis

Authors : Okan BARDAKCI, Murat DAŞ, Hilal ŞEHİTOĞLU, Ece ÜNAL ÇETİN, Ünzile ATALAY, Uğur KÜÇÜK, Fatih KAMIŞ, Alpaslan TANOĞLU, Yavuz BEYAZIT

Pages : 844-849

Doi:10.32322/jhsm.1096501

View : 30 | Download : 12

Publication Date : 2022-05-30

Article Type : Research Paper

Abstract :Background: S100A8/A9 and S100A12 which are the major calcium-binding proinflammatory proteins secreted by granulocytes, has been proposed to be related to distinct disease states of inflammatory origin. This study aims to explore the circulating levels of S100A8/A9 and S100A12 in acute pancreatitis insert ignore into journalissuearticles values(AP); and reveal their relationship with conventional inflammatory markers. Material and Method: Serum S100A8/A9 and S100A12 were determined in AP patients insert ignore into journalissuearticles values(male/female: 17/13); by using a specific enzyme-linked immunosorbent assay insert ignore into journalissuearticles values(ELISA); method at both onset and remission and in 30 healthy controls insert ignore into journalissuearticles values(male/female: 17/13);. Results: Significantly higher S100A8/A9 and S100A12 levels were found in AP patients compared to healthy controls insert ignore into journalissuearticles values(p<0.001);. Circulating levels of S100A8/9, S100A12 and C-reactive protein insert ignore into journalissuearticles values(CRP); were found to be elevated in AP patients at disease onset compared with remission. The correlation analysis demonstrated a significant association between S100A8/A9 and S100A12 insert ignore into journalissuearticles values(r=0.366, p=0.047);. The cut-off level for S100A8/A9 for detecting AP was ≥54.4 ng/ml with a sensitivity and specificity of 96.7% and 73.3% insert ignore into journalissuearticles values(AUC: 0.958);. The optimum cut-off level for S100A12 for detecting AP was ≥350.25 ng/ml with a sensitivity and specificity of 73.3% and 76.7% insert ignore into journalissuearticles values(AUC: 0.752); respectively. Conclusion: Circulating S100A8/A9 and S100A12 levels were found to be elevated in AP patients. Both of these markers might serve as an additional tool in the diagnostic workup in AP since S100A8/A9 and S100A12 were significantly correlated with CRP.
Keywords : Acute pancreatitis, S100A8 A9, S100A12, CRP, inflammation