Integrity loss of glycosylated hemoglobin with deepening anemia

Authors : Bünyamin AYDIN, Aysun GÖNDEREN

Pages : 839-843

Doi:10.32322/jhsm.1098573

View : 21 | Download : 12

Publication Date : 2022-05-30

Article Type : Research Paper

Abstract :Introduction: Iron deficiency anemia insert ignore into journalissuearticles values(IDA); has been shown to cause a false increase in glycosylated hemoglobin insert ignore into journalissuearticles values(HBA1c);, but how much increase in hemoglobin insert ignore into journalissuearticles values(Hgb); causes a certain decrease in HBA1c remains unknown. Knowledge of this ratio will enable more accurate clinical diagnosis and follow-up of diabetes. This study aimed to investigate whether IDA causes a decrease in HBA1c and if it does, how much of a decrease it causes. Material and Method: One hundred and twenty-two patients with IDA made up the study group and sixty-two health volunteers formed the control group. 270 mg ferrous sulphate insert ignore into journalissuearticles values(=80 mg elemental iron); were administered to the study group each day, orally for 3 months, and a control of age/sex matched healthy participants were monitored. Hgb, serum iron, serum iron binding capacity insert ignore into journalissuearticles values(SIBC);, ferritin and HbA1c levels of all participants were measured and compared at baseline and at the third month of the study. Results: There was a significant decrease in HbA1c and SIBC levels at baseline and 3 months in the study group insert ignore into journalissuearticles values(p<0.001, p<0.001, p<0.001 respectively); and a significant increase in serum iron, ferritin and Hgb insert ignore into journalissuearticles values(p<0.001, p<0.001, p<0.001 respectively);. It was found that a 1 mg/dl increase in Hgb level resulted in a 0.113% decrease in HbA1c. Conclusion: As anemia deepens, HBA1c loses its reliability for diagnosis and follow-up of DM. IDA should be considered before any diagnosis or treatment decisions are made according to HbA1c levels.
Keywords : anemia, diabetes, glycosylated hemoglobin