Role of red cell dstribution width in colorectal cancer diagnosis and prognosis

Authors : Ahmet KARAYİĞİT, Dursun Burak ÖZDEMİR, Hayrettin DİZEN, Bülent ÜNAL, İlter OZER, Murat ULAŞ

Pages : 875-881

Doi:10.32322/jhsm.1102938

View : 22 | Download : 11

Publication Date : 2022-05-30

Article Type : Research Paper

Abstract :Objective: We aimed to assess whether red cell distribution width insert ignore into journalissuearticles values(RDW); was associated with pre-operative clinical features or post-operative clinicopathological outcomes in patients with colorectal cancer insert ignore into journalissuearticles values(CRC);, and to determine the utility of RDW as a diagnostic or prognostic marker of CRC. Material and Method: This retrospective cohort study was conducted between January 2018 and May 2021 at a university hospital in Turkey. A total of 188 patients histologically diagnosed with CRC who had undergone surgery were included in the study. Results: Our study included 118 insert ignore into journalissuearticles values(62.77%); male patients, and the mean age of the patients was 66.28±11.71 years. We found that RDW values were significantly higher in females compared to males insert ignore into journalissuearticles values(p=0.033);, in patients with T3 or T4 tumors compared to those with T1 or T2 tumors insert ignore into journalissuearticles values(p<0.001);, in patients with stage 2 and stage 3 tumors compared to stage 1 patients, those with early mortality insert ignore into journalissuearticles values(p=0.012);, in patients with right or transverse colon tumors compared to those with descending colon or sigmoid colon or rectum tumors insert ignore into journalissuearticles values(p<0.001);, and those that died during follow-up compared to survivors insert ignore into journalissuearticles values(p=0.001);. Additionally, age insert ignore into journalissuearticles values(r=0.233, p<0.001);, tumor size insert ignore into journalissuearticles values(r=0.229, p=0.002); and length of stay in hospital insert ignore into journalissuearticles values(r=0.167, p=0.022); were positively correlated with RDW values. RDW had 75.7% sensitivity and 67.5% specificity to predict mortality for the cut-off point of 15.7 insert ignore into journalissuearticles values(AUC: 0.704, 95.0%CI: 0.615-0.793, p<0.001);. Conclusion: These results show that RDW has a potential function as a biomarker for the diagnosis and prognosis of CRC.
Keywords : Colorectal cancer, RDW, prognosis, progression, overall survival