Systemic inflammation indices predict mortality in patients with COVID-19

Authors : Şaziye Melike IŞIK

Pages : 1086-1091

Doi:10.32322/jhsm.1106023

View : 21 | Download : 11

Publication Date : 2022-07-20

Article Type : Research Paper

Abstract :Aim: In recent years, inflammation-based indices obtained from hematologic parameters have been shown to have prognostic value in various inflammatory diseases and cancer types. In this study, we aimed to investigate whether inflammation indices could be used to predict mortality in patients with COVID-19. Material and Method: A total of 295 patients with a proven diagnosis of COVID-19 who were followed up in the intensive care unit were included in this retrospective, cross-sectional study. The patients were divided into two groups, survivors and non-survivors. Results: D-dimer insert ignore into journalissuearticles values(HR:1.001, 95% CI:1-1.001); and troponin insert ignore into journalissuearticles values(HR: 1.001 95% CI: 1-1.001); levels of non-survivors were significantly higher in univariate analyses insert ignore into journalissuearticles values(p<0.05);. Procalcitonin levels of whom were found to be high in univariate insert ignore into journalissuearticles values(HR: 1.018 95% CI: 1.003 – 1.034); and multivariate insert ignore into journalissuearticles values(HR:1.02 95% CI: 1.004-1.037); analyses insert ignore into journalissuearticles values(p<0.05);. There was no significant difference between the groups in terms of median values of PLR, SIRI, and AISI indices insert ignore into journalissuearticles values(p>0.05);. The median NLR value of the survivors was 7.45, while it was 11.39 in the non-survivors, and this difference was statistically significant insert ignore into journalissuearticles values(p<0.001);. The median value of the SII index of the non-survivors was found as 2421.02, which was significantly higher than the survivors insert ignore into journalissuearticles values(p<0.001);. The value of NLR and SII indices in predicting mortality in COVID-19 was evaluated using ROC analysis insert ignore into journalissuearticles values(NLR: AUC=0.644, 95%CI: 0.581-0.708, p<0.001; SII: AUC=0.584, 95%CI: 0.517-0.651, p=0.017);. When the cut-off value for NLR was accepted as 9.574, the sensitivity was 59.3% and the specificity was 67% in predicting mortality. When the cut-off value for SII was accepted as 2285,846, it was found that it could predict mortality with a sensitivity of 52.38% and specificity of 66.04%. Conclusion: SII and NLR indices can predict mortality in patients with COVID-19 followed up in the intensive care unit.
Keywords : COVID 19, inflammatory index, SII, NLR