The relationship of laboratory parameters and mortality of patients followed in intensive care units with COVID-19

Authors : Meltem KARACAN GÖLEN, Dilek YILMAZ OKUYAN, Ömür İLBAN, Mahmut Sami TUTAR, Şaziye Melike IŞIK

Pages : 1015-1022

Doi:10.32322/jhsm.1106106

View : 20 | Download : 12

Publication Date : 2022-07-20

Article Type : Research Paper

Abstract :Aim: We aimed to evaluate the parameters associated with mortality in COVID-19 patients followed up in the intensive care unit. Material and Method: Three hundred twenty-one patients followed up with the diagnosis of COVID-19 were included in the study. Demographic characteristics, laboratory and clinical parameters were compared in patients with and without mortality. Results: A higher intubation rate insert ignore into journalissuearticles values(98.6% vs. 10.9%); and longer hospitalization insert ignore into journalissuearticles values(10.0 vs. 8.0 days); were detected in the non-survivor group insert ignore into journalissuearticles values(p<0.001);. The neutrophil count, ferritin, troponin I, INR, PT, LDH, urea, creatinine, procalcitonin, WBC, CRP, AST, neutrophil/lymphocyte ratio, and CRP/albumin ratio were significantly higher in the non-survivor group, whereas the lymphocyte count, albumin, monocyte, and platelet counts were significantly lower. A multivariate logistic regression model identified endotracheal intubation, high platelet count, low LDH, low albumin, and decreased CRP/albumin ratio as risk factors associated with intensive care unit mortality. Albumin had the highest prognostic accuracy with an AUC of 0.681 insert ignore into journalissuearticles values(95% CI: 0.621-0.742); and the highest sensitivity insert ignore into journalissuearticles values(84.5%);, and the platelet count had the highest specificity insert ignore into journalissuearticles values(69.2%);. Conclusion: Advanced age, intubation status, and duration of intubation were associated with mortality, and it was thought that an increase in LDH levels and CRP/albumin ratio and a decrease in albumin levels and platelet counts had predictive value in predicting mortality
Keywords : COVID 19, intensive care, mortality, laboratory parameters