The relationship between colorectal cancer and gastric histopathology: case-control study

Authors : Berrin YALINBAŞ KAYA, Fuzuli TUĞRUL

Pages : 1145-1150

Doi:10.32322/jhsm.1118677

View : 31 | Download : 14

Publication Date : 2022-07-20

Article Type : Research Paper

Abstract :Aim: The aim of this study was to investigate the gastric histopathological findings insert ignore into journalissuearticles values(Helicobacter pylori insert ignore into journalissuearticles values(H. pylori);, intestinal metaplasia insert ignore into journalissuearticles values(IM);, atrophic gastritis insert ignore into journalissuearticles values(AG);, and dysplasia); in the patients with and without colorectal cancer insert ignore into journalissuearticles values(CRC);. Material and Method: Two hundred ninety five patients insert ignore into journalissuearticles values(160 CRC patients and 135 control individuals); were included in the study. Gastric histopathological findings of the patients who underwent upper gastrointestinal insert ignore into journalissuearticles values(GI); endoscopy were analyzed retrospectively. Results: H. pylori positivity and IM rates in the CRC patient group were significantly higher than the control group insert ignore into journalissuearticles values(58.8%&27.8% and 33.1%&19.5%, p<0.001 and p<0.012, respectively);. In addition, AG, lymphoplasmocytic infiltration, and dysplasia rates were also higher in the CRC patients compared to the control group. But, they were not statistically significant insert ignore into journalissuearticles values(p=0.462, p=0.103, and p=0.195, respectively);. Conclusion: In our study, the frequency of H. pylori and IM in patients with CRC was higher than in the control group. Since the prevalence of H. pylori infection is high in Turkey and H. pylori-related gastric diseases may be potential risk factors for colorectal neoplasia, it is recommended that individuals in the high-risk group to be screened for colonoscopy. Also, upper GI endoscopic examination should be performed to screen for gastric premaling lesions in patients with CRC.
Keywords : Helicobacter pylori, colorectal cancer, intestinal metaplasia