The relationship between subclinical hypothyroidism and vitamin D

Authors : Işılay KALAN SARI, Muhammed Ali COŞKUNER

Pages : 1276-1280

Doi:10.32322/jhsm.1124332

View : 29 | Download : 12

Publication Date : 2022-09-25

Article Type : Research Paper

Abstract :Aim: Vitamin D insert ignore into journalissuearticles values(vitD); is primarily responsible for bone formation and mineralization. However, in recent years, it has been suggested that vitD may play a role as an immune modulator in the development of numerous diseases, including autoimmune diseases. It has been observed that there is an association between chronic autoimmune thyroiditis insert ignore into journalissuearticles values(AIT); and vitD levels. This study aims to investigate whether there are differences in the levels of 25-hydroxy vitamin D [25insert ignore into journalissuearticles values(OH);D], calcium, and phosphorus in patients with subclinical hypothyroidism insert ignore into journalissuearticles values(SCH); due to AIT, in patients with antibody-negative subclinical hypothyroidism insert ignore into journalissuearticles values(ANSCH);, and in healthy control subjects. Material and Method: Data from 50 newly diagnosed patients with SCH insert ignore into journalissuearticles values(35 of whom AIT); and 50 euthyroid and antibody-negative healthy controls who presented to the Department of Endocrinology and Internal Medicine at our hospital between 2018 and 2020 were retrospectively reviewed. Calcium, phosphorus, and 25insert ignore into journalissuearticles values(OH);D levels of patients and controls were compared. Results: Serum 25insert ignore into journalissuearticles values(OH);D levels were significantly lower in patients compared to controls insert ignore into journalissuearticles values(16.2±7.8 ng/ml and 20.4±8.2 ng/ml, respectively; p=0.024);. Serum levels of calcium insert ignore into journalissuearticles values(p=0.081); and phosphorus insert ignore into journalissuearticles values(p=0.712); did not differ between groups. In a subgroup analysis, patients with AIT had significantly lower 25insert ignore into journalissuearticles values(OH);D values than controls insert ignore into journalissuearticles values(p=0.009);. Compared to controls, 25insert ignore into journalissuearticles values(OH);D levels were comparable in the ANSCH group insert ignore into journalissuearticles values(p=0.096);. 25insert ignore into journalissuearticles values(OH);D level was higher in the AIT group than in the ANSCH group insert ignore into journalissuearticles values(p=0.01);. Conclusion: Our results show that patients with SCH have lower 25insert ignore into journalissuearticles values(OH);D levels than healthy controls. However, this difference is significant in patients with AIT. It is recommended to screen for vitD deficiency in patients with SCH due to AIT.
Keywords : Chronic autoimmune thyroiditis, 25 hydroxy vitamin D, subclinical hypothyroidism