Evaluation of treatment results of stereotactic body radiotherapy for spinal metastases: A single center experience

Authors : Uğur YILMAZ, Gökhan YAPRAK, Naciye IŞIK

Pages : 1215-1219

Doi:10.32322/jhsm.1134145

View : 21 | Download : 9

Publication Date : 2022-09-25

Article Type : Research Paper

Abstract :Aim: To assess oncological outcomes and adverse events of patients receiving single or multi-fraction stereotactic body radiotherapy insert ignore into journalissuearticles values(SBRT); for spine metastases. Material and Method: Patients with any pathologically proven solid tumor histology who had SBRT to the spine for recurrent or metastatic disease between the years 2010 and 2021 at our department were identified from institutional database. Patient, tumor and treatment characteristics, and follow-up medical records were retrospectively reviewed. Local control insert ignore into journalissuearticles values(LC); and overall survival insert ignore into journalissuearticles values(OS); rates were calculated, and adverse events were evaluated. Results: A total of 47 patients were treated to 50 spine metastases. Median age was 53 years for all patients. Histologies included breast cancer insert ignore into journalissuearticles values(45%);, non-small cell lung cancer insert ignore into journalissuearticles values(NSCLC; 21%);, prostate cancer insert ignore into journalissuearticles values(15%); and other types insert ignore into journalissuearticles values(19%);. Median follow-up was 16 months for all patients. Of 47 patients, six insert ignore into journalissuearticles values(13%); developed local failure and 15 insert ignore into journalissuearticles values(32%); died without local failure. One and two-year actuarial LC rates were 90.1% and 83.6%, respectively. One and two-year OS rates were 75.1% and 62.7%, respectively. Twenty-two insert ignore into journalissuearticles values(47%); patients had pain before SBRT. Fifteen insert ignore into journalissuearticles values(68%); of them had complete or partial pain response at 3 months after SBRT. Vertebral compression fracture, which was grade 1 in severity according to the Common Terminology Criteria for Adverse Events insert ignore into journalissuearticles values(CTCAE [v.4.03]);, was observed in only one insert ignore into journalissuearticles values(2%); patient and it occurred 46 months after SBRT. No cases of treatment-related radiation myelopathy or any≥grade 3 RT induced acute or late toxicities occurred. Conclusion: This study supports that SBRT to the spine results in high LC without any significant toxicity. The results of ongoing phase 3 trials will highlight whether this high LC benefit reflects to survival in oligometastatic disease.
Keywords : Stereotactic radiotherapy, Spine, Metastasis