Concordance of histopathological and radiological grading in soft tissue sarcomas

Authors : Begumhan BAYSAL, Fikret Berkan ANARAT, Mahmut Bilal DOGAN, Tulay ZENGİNKİNET, Aykut CELİK, Ayse Nur TOKSOZ, Tarık SARI, Korhan ÖZKAN

Pages : 1484-1490

Doi:10.32322/jhsm.1153412

View : 27 | Download : 13

Publication Date : 2022-09-25

Article Type : Research Paper

Abstract :Aim: The grade of the tumor is essential for planning the treatment strategy in soft-tissue sarcomas insert ignore into journalissuearticles values(STS);. The goal of this study is to determine magnetic resonance imaging features related to histopathological grade and aggressiveness of STS. Material and Method: This retrospective single-center study involved preoperative contrast-enhanced MRI examinations of 64 patients with STS. MRI findings evaluated were; heterogeneity, necrosis, hemorrhage, and relationship with surrounding tissue in T1-weighted insert ignore into journalissuearticles values(T1W);, T2-weighted insert ignore into journalissuearticles values(T2W);, and T1W post-contrast sequences of the lesion. Histological grade was determined with the Fédération Nationale des Centres de Lutte Contre Le Cancer insert ignore into journalissuearticles values(FNCLCC); grading system, and the aggressiveness of the lesion was measured with the Ki-67 index. Results: Sixty-four patients insert ignore into journalissuearticles values(mean age 45.5±21.6, M/F ratio 34/30); with STS were included. 33 insert ignore into journalissuearticles values(51.6%); patients graded as FNCLCC grade 3. On MRI examinations, the absence of necrosis was significantly associated with FNCLCC grade 1 and a low Ki-67 index insert ignore into journalissuearticles values(p<0.001);. The presence of hemorrhage signal distinguished as a hyperintense signal on T1W, tail sign, and post-contrast peritumoral enhancement was significantly higher in FNCLCC grade 3 soft tissue sarcomas insert ignore into journalissuearticles values(p:0.008, p:0.001, p:0.004, respectively);. The presence of peritumoral edema on T2W imaging in all high-grade patients also showed a strong relationship between these two insert ignore into journalissuearticles values(p:0.001);. Conclusion: Our study found that the presence of hemorrhage signal, tail sign, peritumoral enhancement, clear borders of 50% and less obtained from conventional MRI features of soft tissue sarcomas are associated with high grade tumors. The absence of necrosis signal, clear borders of 90% and above in MRI were significantly associated with FNCLCC grade 1.
Keywords : Magnetic resonance imaging, FNCLCC grading, soft tissue sarcoma