Platelet-to-lymphocyte ratio and mean platelet volume-to-platelet count ratio for predicting mortality in critical COVID-19 patients

Authors : Hayriye CANKAR DAL, Kudret Yasemin YALNIZ, Damla TOSUN, Bilge GÖZÜKARA, Hülya ŞİRİN, Cihangir DOĞU, Dilek ÖZTÜRK KAZANCI, Sema TURAN

Pages : 1512-1517

Doi:10.32322/jhsm.1160392

View : 46 | Download : 11

Publication Date : 2022-10-25

Article Type : Research Paper

Abstract :Introduction: Defining the markers that can be used in clinical practice for predicting the mortality of critical patients will be cautionary for taking necessary measures in high-risk cases. Although there are a large number of studies conducted during the pandemic, no mortality marker to predict the prognosis of intensive care unit insert ignore into journalissuearticles values(ICU); patients with COVID-19 has yet been defined. Platelet indices can be easily evaluated with a complete blood count insert ignore into journalissuearticles values(CBC); analysis, one of the most accessible tests worldwide. This study aimed to evaluate the role of platelet indices such as mean platelet volume insert ignore into journalissuearticles values(MPV);, platelet distribution width insert ignore into journalissuearticles values(PDW);, plateletcrit insert ignore into journalissuearticles values(PCT);, platelet-to-lymphocyte ratio insert ignore into journalissuearticles values(PLR);, and MPV-to-platelet count ratio insert ignore into journalissuearticles values(MPV/PLT); in predicting the mortality of ICU patients with COVID-19. Material and Method: This single-center, retrospective, cross-sectional study included 201 critical COVID-19 patients over 18 years of age who were hospitalized in ICU between August 2020 and February 2021. Patients were divided into two groups as survivors and non-survivors. The relationship of MPV, PDW, PCT, PLR, and MPV/PLT parameters evaluated at ICU admission with mortality was investigated. Results: There was no significant difference between the survivor and non-survivor groups in terms of platelet count, MPV, PCT, and PDW. The comparison of the platelet ratios revealed higher PLR and MPV/PLT ratio in the non-survivor group than in the survivor group insert ignore into journalissuearticles values(p<0.05);. The cut-off value of PLR for predicting mortality was found to be 292.20 insert ignore into journalissuearticles values(AUC: 0.601 [95% CI 0.522-0.681]); insert ignore into journalissuearticles values(p<0.05);, while the cut-off of MPV/PLT was found to be 0.0289 insert ignore into journalissuearticles values(AUC: 0.590 [95% CI 0.510-0.671]); insert ignore into journalissuearticles values(p<0.05);. Conclusion: The results of this study demonstrated PLR and MPV/PLT ratio were associated with mortality. The use of ratios such as MPV/PLT and PLR as an early prognostic indicator instead of platelet indices alone, like MPV in ICU patients with COVID-19, may help identify high-risk patients early.
Keywords : COVID 19, mortality, PLR, MPV PLT, intensive care

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