Comparison of culture-positive and culture-negative severe infectious keratitis leading to hospitalization: a tertiary referral center experience

Authors : Nesrin TUTAŞ GÜNAYDIN, Baran KANDEMİR, Gizem DOGAN GOKCE, Mehmet Can ÖZEN, Raziye DÖNMEZ GÜN, Demet HACISEYİTOĞLU

Pages : 1612-1618

Doi:10.32322/jhsm.1176813

View : 47 | Download : 14

Publication Date : 2022-10-25

Article Type : Research Paper

Abstract :Aim: To compare the predisposing factors, surgical interventions, length of hospital stay insert ignore into journalissuearticles values(LOHS);, and treatment outcomes of culture-positive insert ignore into journalissuearticles values(CP); versus culture-negative insert ignore into journalissuearticles values(CN); severe infectious keratitis insert ignore into journalissuearticles values(IK); resulting in hospitalization in a tertiary referral clinic. Material and Method: We retrospectively reviewed the medical and microbiological records of 287 patients clinically diagnosed with severe keratitis over a 4-year period. Results: Of 287 study participants, 141 insert ignore into journalissuearticles values(49.1%); had positive CP results. The most common ocular risk factor was a previous ocular surgery insert ignore into journalissuearticles values(45.6%);, and keratoplasty was the first among these ocular surgeries insert ignore into journalissuearticles values(90.8%);. Staphylococcus epidermidis insert ignore into journalissuearticles values(22.7%); was the most commonly isolated microorganism followed by fungi insert ignore into journalissuearticles values(17.7%);. The initial and final visual acuities did not differ significantly between the CP and CN groups. Major and minor surgical interventions did not significantly differ between the groups insert ignore into journalissuearticles values(p=0.05);. The rates of clear corneal graft in the CP group insert ignore into journalissuearticles values(p =0.002); were significantly higher than the rates of graft failure in the CN group insert ignore into journalissuearticles values(p=0.033);. No significant difference was noted in the mean LOHS between groups insert ignore into journalissuearticles values(p=0.66);. Logistic regression analyses showed that surgery during admission, S. epidermidis infection, and connective tissue diseases were independent risk factors for a prolonged hospital stay. Conclusion: The initial and final visual acuities, surgical interventions, and LOHS were similar between the CP and CN groups. However, graft failure rates were significantly higher in patients with CN keratitis than in those with CP keratitis.
Keywords : Infectious keratitis, microbial culture, Staphylococcus epidermidis, hospitalization

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