The findings about relationship between autoimmune thyroid disease and first-trimester aneuploidy results

Authors : Naziye GÜRKAN, Halime ÇALI ÖZTÜRK

Pages : 1661-1665

Doi:10.32322/jhsm.1179194

View : 42 | Download : 14

Publication Date : 2022-10-25

Article Type : Research Paper

Abstract :Aim: The aim of this study was to investigate the relationship between thyroid autoantibody and first-trimester aneuploidy results. Thyroid autoimmunity insert ignore into journalissuearticles values(TAI); is the most common autoimmune disorder. Patients with TAI are usually euthyroid. Thyroid peroxidase insert ignore into journalissuearticles values(TPO-Ab); in patients with or without thyroid dysfunction is associated with infertility, recurrent embryo implantation failure, and early pregnancy loss. The impact of TPO-Ab on first-trimester aneuploidy test results needs to be studied. Material and Method: This retrospective case-control study was conducted between December 2019 and May 2022. Patients with thyroid autoantibody positivity insert ignore into journalissuearticles values(n=112); were included in the study as the case group. The control group was selected from age and body mass index insert ignore into journalissuearticles values(BMI);-matched patients insert ignore into journalissuearticles values(n=130);. Nuchal translucency insert ignore into journalissuearticles values(NT);, crown rump length insert ignore into journalissuearticles values(CRL);, pregnancy-associated plasma protein A insert ignore into journalissuearticles values(PAPP-A); and free beta subunit of human chorionic gonadotropin insert ignore into journalissuearticles values(β-hCG);); values were compared between the two groups. Results: This study included two hundred forty two age-matched insert ignore into journalissuearticles values(29.86±4.51); and BMI-matched insert ignore into journalissuearticles values(23.96±2.34); women. There was no statistically significant difference between groups in terms of free thyroxine insert ignore into journalissuearticles values(FT4);, PAPP-A and free β-hCG insert ignore into journalissuearticles values(p>0.05);. NT as a marker for major chromosomal defects and CRL were comparable in case and control groups insert ignore into journalissuearticles values(p>0.05);. Conclusion: There is no statistically significant relationship between thyroid autoimmune diseases and the first-trimester aneuploidy results.
Keywords : Aneuploidy, thyroid, autoimmune thyroid disease

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