Is there any effect of long term alpha-adrenergic blocker and a single dose antibiotic usage in reducing febrile urinary tract infections after prostate biopsy?

Kubilay SARIKAYA; Muhammed Arif İBİŞ

doi:10.32322/jhsm.1138430

Is there any effect of long term alpha-adrenergic blocker and a single dose antibiotic usage in reducing febrile urinary tract infections after prostate biopsy?

Authors : Kubilay SARIKAYA, Muhammed Arif İBİŞ

Pages : 1-6

Doi:10.32322/jhsm.1138430

View : 74 | Download : 15

Publication Date : 2023-01-12

Article Type : Research Paper

Abstract :Aim: To investigate whether the using long term alpha-adrenergic blockers before biopsy has an effect on preventing febrile urinary tract infections insert ignore into journalissuearticles values(FUI); secondary to biopsy in patients undergoing prostate biopsy due to elevated prostate specific antigen insert ignore into journalissuearticles values(PSA); . Material and Method: The data of 2558 patients who underwent transrectal ultrasonography-guided prostate biopsy insert ignore into journalissuearticles values(TRUS+BX); due to elevated PSA in our clinic between January 2008 and July 2021 were analyzed retrospectively. The patients were divided into two groups as those who used alpha-blockers for a minimum of three months or longer before biopsy insert ignore into journalissuearticles values(Group 1); and those who did not use alpha-blockers before applying to the outpatient clinic insert ignore into journalissuearticles values(Group 2); . Demographic data of the groups and post-biopsy FUI development rates were compared. Results: It was observed that 1340 insert ignore into journalissuearticles values(52.4%); of the patients were using alpha-blockers insert ignore into journalissuearticles values(Group 1); and 1218 insert ignore into journalissuearticles values(47.6%); did not insert ignore into journalissuearticles values(Group 2); . The median age of the patients in the pre-biopsy groups was similar [Group 1=68 insert ignore into journalissuearticles values(IQR=9); years and Group 2=68 insert ignore into journalissuearticles values(IQR=9); years, p=0.887]. There was no significant difference between the groups in terms of median prostate volume [Group1=57 insert ignore into journalissuearticles values(31); ml and Group 2=58 insert ignore into journalissuearticles values(34); ml, p=0.199]. The median PSA value was found to be significantly higher in Group 1 than in Group 2 [10.50 insert ignore into journalissuearticles values(5.40); ng/dl vs 10.35 insert ignore into journalissuearticles values(6.80); ng/dl, p=0.026]. Postvoid residual urine volume insert ignore into journalissuearticles values(PVR); was found to be significantly higher in Group 2 [Group 1=40 insert ignore into journalissuearticles values(30); ml and Group2=60 insert ignore into journalissuearticles values(90); ml, p<0.001]. Similarly, the frequency of FUI development after biopsy was found to be significantly higher in Group 2 [Group 1=17 insert ignore into journalissuearticles values(1.3%); and Group 2=65 insert ignore into journalissuearticles values(5.3%); , p<0.001]. Conclusion: The use of alpha-adrenergic blockers for a minimum of three months or longer before prostate biopsy significantly reduces the incidence of FUI that may develop secondary to biopsy.
Keywords : Urinary tract infection, prostate, core needle biopsy

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