Association between atherogenic index of plasma and in-hospital mortality in patients with STEMI undergoing primary percutaneous coronary intervention

Authors : Hacı Ahmet KASAPKARA, Mehmet ERDOĞAN

Pages : 158-164

Doi:10.32322/jhsm.1218420

View : 46 | Download : 14

Publication Date : 2023-01-12

Article Type : Research Paper

Abstract :Aim: Dyslipidemia is an established risk factor for cardiovascular disease. Increased triglyceride insert ignore into journalissuearticles values(TG);, low-density lipoprotein cholesterol insert ignore into journalissuearticles values(LDL-C); levels, and decreased high lipoprotein cholesterol insert ignore into journalissuearticles values(HDL-C); levels were associated with increased cardiovascular risk. Recently, comprehensive lipid profile indices derived from these conventional parameters have attracted to attention. Atherogenic index of plasma insert ignore into journalissuearticles values(AIP); is one of the indices calculated as the logarithm of TG/HDL-C levels and it is accepted as an alternative and simple marker of plasma atherogenicity. Although various studies demonstrated that their relationship with these lipid indices and clinical outcomes in patients with acute coronary syndrome, this situation is not yet clear in acute ST-elevation myocardial infarction insert ignore into journalissuearticles values(STEMI); patients undergoing primer percutaneous coronary intervention insert ignore into journalissuearticles values(pPCI);. In this study, we aimed to investigate the relationship of AIP with early mortality in STEMI patients undergoing pPCI. Material and Method: This is a retrospective, single center, hospital-based study carried out between January 2019 and April 2021. A total of 873 consecutive STEMI patients insert ignore into journalissuearticles values(705 men; median age 59 years);, whose undergoing pPCI, were enrolled. The patients were divided into two groups according to in-hospital mortality status namely survivors vs non-survivors. Conventional lipid values were measured and non-traditional lipid indexes including non-HDL-C [Total cholesterol minus HDL-C], Total cholesterol/HDL-C, LDL-C/HDL-C, atherogenic index insert ignore into journalissuearticles values(AI); [non-HDL-C/HDL-C], lipoprotein combine index insert ignore into journalissuearticles values(LCI); [Total cholesterol*TG*LDL-C/HDL-C] and atherogenic index of plasma insert ignore into journalissuearticles values(AIP); [Loginsert ignore into journalissuearticles values(TG/HDL-C);] were calculated. Angiographic images of the patients were evaluated through the hospital automation system. Results: AIP was significantly higher in non-survivors compared to survivor group insert ignore into journalissuearticles values(0.59, 0.47, p=0.006, respectively);. AI, non-HDL-C, Total cholesterol/HDL-C ratio, LDL-C/HDL-C ratio and LCI measurements were similar between two groups. The cut-off value of the AIP insert ignore into journalissuearticles values(0.50); was associated with 70% sensitivity and 52% specificity for predicts in-hospital mortality. Multivariate logistic regression model indicated AIP insert ignore into journalissuearticles values(OR: 3.77, 95% CI: 1.34–10.6, p < 0.012); as independent predictor of in-hospital mortality in STEMI patients undergoing pPCI. Conclusion: AIP predicts in-hospital mortality in patients with STEMI undergoing pPCI. AIP, which can be calculated easily by complete blood can be beneficial in evaluating the prognosis of these patients.
Keywords : Atherogenic index of plasma, Acute myocardial infarction, Dyslipidemia, Atherogenic index of plasma, acute myocardial infarction, dyslipidemia

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