R-Spondin1 and tumor necrosis factor-alpha in infertile women with polycystic ovary syndrome: relationships with insulin resistance and other parameters

Authors : Tuğba GÜRBÜZ, Oya GÖKMEN, Asena AYAR MADENLİ, Berna DİLBAZ

Pages : 449-455

Doi:10.32322/jhsm.1210721

View : 21 | Download : 13

Publication Date : 2023-03-27

Article Type : Research Paper

Abstract :Aim: To evaluate the relationship between R-spondin1 insert ignore into journalissuearticles values(RSPO1); and Tumor Necrosis Factor-Alpha insert ignore into journalissuearticles values(TNF-α); levels with insulin resistance insert ignore into journalissuearticles values(IR); and other parameters in infertile women with polycystic ovary syndrome insert ignore into journalissuearticles values(PCOS);. Material and Method: This case-control prospective observational study was carried out on 84 patients admitted to the University of Health Sciences Etlik Zübeyde Hanım Training and Research Hospital Gynecology and IVF Clinic and Medistate Hospital Gynecology and IVF Clinic between September 2020 and June 2021. Women aged 18-36 years diagnosed with infertility and PCOS constituted the PCOS group. Women who were diagnosed with infertility but not PCOS formed the control group. Cases were divided according to their body mass index insert ignore into journalissuearticles values(BMI); values into obese insert ignore into journalissuearticles values(BMI≥25); and non-obese insert ignore into journalissuearticles values(BMI<25); groups. Results: The mean age of the study group was 26.9±5.37 years. RSPO1 and TNF-α levels were higher in PCOS patients insert ignore into journalissuearticles values(p<0.001);. Hip circumference insert ignore into journalissuearticles values(HC); was found to be higher in those with a diagnosis of PCOS insert ignore into journalissuearticles values(p<0.001);. The group with the highest waist-to-hip ratio insert ignore into journalissuearticles values(WHR); was the obese-PCOS group insert ignore into journalissuearticles values(p<0.001);. Glucose, insulin, and homeostatic model assessment for IR insert ignore into journalissuearticles values(HOMA-IR); levels were the highest in the obese-PCOS group insert ignore into journalissuearticles values(p<0.001);. A positive correlation was found between RSPO1 and TNF-α insert ignore into journalissuearticles values(r=0.944, p<0.001);. There was a positive correlation between the hip circumference and RSPO1 insert ignore into journalissuearticles values(r=0.255, p=0.0019); and TNF-α insert ignore into journalissuearticles values(r=0. 0.278, p=0.011);. There were positive correlations between blood glucose and RSPO1 insert ignore into journalissuearticles values(r=0.343, p=0.001); and TNF-α levels insert ignore into journalissuearticles values(r=0.312, p=0.004); and between insulin and RSPO1 insert ignore into journalissuearticles values(r value=0.577, p<0.001); and TNF-α levels insert ignore into journalissuearticles values(r=0.569, p<0.001);. HOMA-IR values were also found to correlate with RSPO-1 and TNF-α levels insert ignore into journalissuearticles values(r= 0.619 and 0.608, p<0.001);. Conclusion: It can be concluded that RSPO1 and TNF-α levels may guide the assessment and management of IR and diabetes risk in infertile women with PCOS.
Keywords : Polycystic ovary syndrome, R Spondin1, Tumor Necrosis Factor alpha, obesity, insulin resistance