The usefulness of arylesterase in predicting contrast-induced nephropathy in ST-segment elevation myocardial infarction patients undergoing percutaneous coronary intervention

Authors : Süleyman KALAYCI, Ayse Ceylan HAMAMCIOGLU, Belma KALAYCI

Pages : 244-249

Doi:10.32322/jhsm.1221793

View : 21 | Download : 10

Publication Date : 2023-03-27

Article Type : Research Paper

Abstract :Aim: Oxidative stress is one of the causes of contrast-induced nephropathy insert ignore into journalissuearticles values(CIN);. Paraoxonase1 insert ignore into journalissuearticles values(PON1);, is one of the oxidative stress markers. The most sensitive method that has been in use to measure PON1 enzyme activity is the measurement of arylesterase insert ignore into journalissuearticles values(AREase); activity. To explore relationship between AREase activity and CIN development. Material and Method: A total of 58 STEMI patients were included in our study. The patients were divided into two groups as CIN insert ignore into journalissuearticles values(+); and CIN insert ignore into journalissuearticles values(-);. The success of AREase activity level in predicting the development of CIN was also examined by using ROC analysis. Results: Out of the study patients, 13 were CIN insert ignore into journalissuearticles values(+); and 45 were CIN insert ignore into journalissuearticles values(-);. AREase activity was found to be statistically significantly lower in the CIN insert ignore into journalissuearticles values(+); group insert ignore into journalissuearticles values(875 U/L vs 819 U/L, p= 0.004);. In the regression analysis, diabetes mellitus, contrast volume and AREase activity were determined as independent risk factors in the development of CIN. As a result of the ROC analysis, we concluded that the AREase activity level <824.1 U/L predicted the development of CIN with 61.5% sensitivity and 86.7% specificity insert ignore into journalissuearticles values(AUC= 0.768, 95% CI= 0.638-0.868, p=0.001);. Conclusion: AREase level is an independent risk factor for the development of CIN and can be used for the prediction of CIN development.
Keywords : Acute myocardial infarction STEMI, Angiography, Coronary, Coronary Artery Disease, Percutaneous Coronary Intervention PCI, Renal Disease, Acute, Acute myocardial infarction, Coronary Artery Disease, Coronary Art