Is neutrophil lymphocyte ratio magic or not?

Authors : Fatih SAHİN, Ali Şahap ODACILAR, Osman Samet GÜNKAYA, Ramazan ADAN, Enes SARAÇ, Simten GENÇ, Arzu YURCİ, Ozgur AKBAYİR

Pages : 618-622

Doi:10.32322/jhsm.1246871

View : 93 | Download : 153

Publication Date : 2023-05-31

Article Type : Research Paper

Abstract :Aim: To evaluate the predictive value of preoperative ratio of neutrophils to lymphocytes insert ignore into journalissuearticles values(NLR); in distinguishing between benign and malignant masses, as inflammation plays a significant role in the development and emergence of cancer. Material and Method: This retrospective study included 155 patients who underwent surgery due to an adnexal mass between December 2020 and December 2021 insert ignore into journalissuearticles values(55 were malignant, 100 were benign);. Age, parity, tumor stage, chemotherapy, CA 125, CRP, neutrophils, lymphocytes, NLR, were recorded. The Mann-Whitney, the Chi-square test and multiple linear regression were used. The cut-off values of the variables were determined by calculating the areas under the receiver operating characteristic curve insert ignore into journalissuearticles values(ROC); for the purposes of differential diagnosis in the presence of malignancy, and by analyzing the sensitivity, specificity, positive predictive value, negative predictive value, and likelihood-ratio insert ignore into journalissuearticles values(LR); insert ignore into journalissuearticles values(+); values. A P-value of 2.79 for NLR; sensitivity was found to be 59.36%, specificity 75.51%, positive predictive value insert ignore into journalissuearticles values(PPV); 58.44, negative predictive value 75.58, LR insert ignore into journalissuearticles values(+); value 2.3. At cut-off> 36.9 for CA-125; sensitivity was 80.00%, specificity was 78.63%, positive predictive value was 67.72%, negative predictive value was 87.53%, LR insert ignore into journalissuearticles values(+); value was 3.73. Conclusion: The primary outcome of our study is that the likelihood of malignancy in a patient with an NLR value of>2.79 is 2.3 times higher than in a patient with an NLR value of 36.9 is 3.73 times higher than in a patient with a CA-125 value of <36.9.
Keywords : NLR, CA 125, ovarian cancer