The relationship between Hashimoto`s thyroiditis and vitamin D and the inflammatory marker platelet-to-lymphocyte ratio

Authors : Gönül KOÇ, Ayşe ARSLANSÜZER, Gül GÜRSOY

Pages : 693-698

Doi:10.32322/jhsm.1293585

View : 68 | Download : 68

Publication Date : 2023-05-31

Article Type : Research Paper

Abstract :Aim: Hashimoto\`s thyroiditis insert ignore into journalissuearticles values(HT); is a chronic autoimmune-mediated disease that leads to overt hypothyroidism. Vitamin D is essential for immunity. This study examines possible impacts of vitamin D on the progression of HT and evaluates the use of platelet-lymphocyte ratio insert ignore into journalissuearticles values(PLR); as an indicator of its relationship with the inflammatory process. Material and Method: This is a retrospective case-control study, consisting of 60 individuals with HT and 40 healthy controls. Thyroid function tests, thyroid antibodies, vitamin D levels, erythrocyte sedimentation rate insert ignore into journalissuearticles values(ESR);, parameters of complete blood count and C-reactive protein insert ignore into journalissuearticles values(CRP); levels were scanned retrospectively using participants\` medical files between September 2018 and March 2019. Platelet count was divided by lymphocyte count to determine PLR. Results: HT patients had both considerably lower median vitamin D levels and higher percentages of vitamin D deficiency than the controls [12.08 insert ignore into journalissuearticles values(8.79–17.00); vs. 20.09 insert ignore into journalissuearticles values(20.00–34.00); and 80% vs. 22.5%, respectively, p<0.001);. Vitamin D deficiency was also higher within the hypothyroid HT group than in the euthyroid HT group insert ignore into journalissuearticles values(p<0.001);. The vitamin D levels of HT patients with subclinical hypothyroidism were lower than those with euthyroidism insert ignore into journalissuearticles values(p<0.004);. The study groups showed no differences regarding CRP levels, higher levels of ESR were reported only in the overt hypothyroid patients insert ignore into journalissuearticles values(p=0.001);, and higher PLRs were found in those euthyroid HT patients. Vitamin D was negatively correlated with TSH and anti-thyroid peroxidase insert ignore into journalissuearticles values(anti-TPO); levels insert ignore into journalissuearticles values(r=−0.294, p=0.023; r=−0.281, p=0.030, respectively);. A positive correlation existed between TSH and anti-TPO insert ignore into journalissuearticles values(r=0.411, p=0.001); and ESR insert ignore into journalissuearticles values(r=0.365, p=0.002);, but TSH and PLR were negatively correlated insert ignore into journalissuearticles values(r=−0.390, p=0.002);. Conclusion: According to these findings, vitamin D may play a role in the transition to the hypothyroid phase in HT patients, and thus, vitamin D replacement may inhibit this progression. Moreover, our results indicate that PLR may not be a good inflammatory indicator for vitamin D-deficient HT patients.
Keywords : Hashimoto, vitamin D, platelet lymphocyte ratio, autoimmune thyroiditis, hypothyroidism, inflammation