The use of fetal bovine acellular dermal matrix for management of chronic wounds

Authors : Tuna GÜMÜŞ

Pages : 713-719

Doi:10.32322/jhsm.1261658

View : 238 | Download : 213

Publication Date : 2023-07-30

Article Type : Research Paper

Abstract :Aims: In the treatment of chronic wounds, tissue growth must be addressed and optimized. The purpose of this study is to investigate the use of the regenerative medicinal product Fetal Bovine Acellular Dermal Matrix insert ignore into journalissuearticles values(FBADM); in chronic wounds. Methods: The patients were chosen sporadically and randomly based on availability to FBADM. Patients were assessed for adequate perfusion, debridement was performed, and wounds were ensured to be free of infection. FBADM was placed in the wound bed covered with a non-adherent contact layer, and a hydrogel sheet was placed to maintain adequate moisture. Offloading or compression was used as clinically indicated. Patients were then followed weekly. Digital photography was used to visually document healing progress. Results: After 1-3 weeks wounds managed with FBADM had improved characteristics and healthy vascularized tissue that subsequently epithelialized from wound margins or grafted with split thickness skin grafts. Of the 14 wounds we achieved 69% complete healing, 24% non-complete healing after 12 weeks of FBADM application. 7% of the wounds needed skin graft surgery. Conclusion: We found FBADM to be useful for treatment regimen of diabetic foot and leg ulcers, venous leg ulcers, surgical wounds, and wounds being prepared for skin grafting.
Keywords : Chronic wounds, extracellular matrix, tissue engineering, skin substitutes