The success of volumetric means ADC in predicting MGMT promoter hypermethylation in glioblastomas

Authors : Serhat KORKMAZ, Emin DEMIREL

Pages : 767-771

Doi:10.32322/jhsm.1311867

View : 95 | Download : 85

Publication Date : 2023-07-30

Article Type : Research Paper

Abstract :Aims: This study aimed to investigate the relationship between volumetric mean ADC values and MGMT promoter hypermethylation status in glioblastoma insert ignore into journalissuearticles values(GB); patients segmented into perilesional edema area, solid tumor area, and necrosis area. Methods: The 212 GB patients in the University of California San Francisco Preoperative Diffuse Glioma MRI insert ignore into journalissuearticles values(UCSF-PDGM); dataset were retrieved from the Cancer Imaging Archive insert ignore into journalissuearticles values(TCIA);. The mean volumetric ADC value was calculated in patients with shared segmentation data in the UCSF-PDGM dataset. The difference in mean volumetric ADC value was investigated in patients divided into groups based on MGMT promoter hypermethylation insert ignore into journalissuearticles values(MGMT+/ MGMT-);. Results: Of the patients in our study, 125 insert ignore into journalissuearticles values(59.0%); were male. The median age of the patients was 62 years insert ignore into journalissuearticles values(26-94);. MGMT promoter hypermethylation was observed in 152 insert ignore into journalissuearticles values(71.7%); patients. Mean Survival was calculated as 574.14±345.57 days in the MGMT+ group and 484.68±301.71 days in MGMT- group. According to volumetric mean ADC values, a difference was observed in the solid tumor and perilesional edema areas according to MGMT promoter hypermethylation insert ignore into journalissuearticles values(p 1.14 in ADC measurements from the edema area with 72% sensitivity and 90% specificity. MGMT+ group could be determined with a sensitivity of 88% and specificity of 69% with a cut-off value of >1.01 in ADC measurements from the solid tumor area. Conclusion: Volumetric ADC measurements from the perilesional edema and solid tumor areas revealed higher ADC values in the MGMT+ group.
Keywords : Glioblastoma, diffusion magnetic resonance imaging, MGMT hypermethylation, apparent diffusion coefficient ADC,