Impact of Ramadan fasting on eGFR in patients with late stage chronic kidney disease

Authors : Mahmud İSLAM

Pages : 1016-1021

View : 52 | Download : 47

Publication Date : 2023-09-28

Article Type : Research Paper

Abstract :Aims: Ramadan fasting is a significant religious practice observed annually by approximately 1.9 billion adult Muslims worldwide. However, its potential impact on kidney health in individuals with chronic kidney disease insert ignore into journalissuearticles values(CKD); remains a subject of concern. This study aimed to investigate the effects of Ramadan fasting on renal function in patients with stage 3-5 CKD and to identify any associated risk factors. Methods: A single-center, self-controlled longitudinal observational study was conducted on 192 stable patients with stage 3-5 CKD who observed Ramadan fasting. The fasting period was about 14-15 hours per day for one month Various clinical parameters, including eGFR, blood urea nitrogen insert ignore into journalissuearticles values(BUN);, sodium insert ignore into journalissuearticles values(Na+);, potassium insert ignore into journalissuearticles values(K+);, calcium insert ignore into journalissuearticles values(Ca++);, phosphorus, parathyroid hormone insert ignore into journalissuearticles values(PTH);, albumin, uric acid, fasting glucose, total cholesterol, triglyceride, high-density lipoprotein insert ignore into journalissuearticles values(HDL); cholesterol, low-density lipoprotein insert ignore into journalissuearticles values(LDL); cholesterol, and hemoglobin insert ignore into journalissuearticles values(Hgb);, were measured before and after Ramadan fasting. P 0.05);. Furthermore, the use of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers insert ignore into journalissuearticles values(ACEi/ARB); did not impact eGFR insert ignore into journalissuearticles values(0.084);. Notably, Ramadan fasting led to improvements in metabolic parameters, such as fasting glucose and lipid profile, except for triglyceride levels insert ignore into journalissuearticles values(p<0.001);. Conclusion: The study results indicate that Ramadan fasting does not appear to have adverse effects on kidney function in individuals with CKD, although certain metabolic changes were observed.
Keywords : Ramadan fasting, chronic kidney disease, glomerular filtration rate, metabolic parameters, kidney function