The role of disease activity as a determinant of body awareness and central sensitization in patients with axial spondyloarthritis: a cross-sectional study

Authors : Hakan APAYDIN, Zilan BAZANCİR APAYDIN

Pages : 1022-1028

View : 51 | Download : 40

Publication Date : 2023-09-28

Article Type : Research Paper

Abstract :Aims: The aim of this study was to investigate the effects of disease activity on body awareness and central sensitization in patients with axial spondyloarthritis insert ignore into journalissuearticles values(axSpA);. Methods: This cross-sectional study included patients diagnosed with axSpA. Disease activity was evaluated using the Bath Ankylosing Spondylitis Disease Activity Index insert ignore into journalissuearticles values(BASDAI);, and a score of four or higher was considered high disease activity. Patients were divided into two groups according to BASDAI: high disease activity insert ignore into journalissuearticles values(BASDAI ≥ 4); group insert ignore into journalissuearticles values(HG); and the low disease activity insert ignore into journalissuearticles values(BASDAI 0.05);. The CSI-A score was higher in HG compared to LG insert ignore into journalissuearticles values(44 insert ignore into journalissuearticles values(31-54); vs. 31 insert ignore into journalissuearticles values(21-41);, p=0.008);. The HG had poorer BAQ scores than the LG insert ignore into journalissuearticles values(61 insert ignore into journalissuearticles values(52-85); vs. 85 insert ignore into journalissuearticles values(64-96);, p=0.017);. BASDAI was moderately associated with CSI-A insert ignore into journalissuearticles values(r=0.145, R2=0.172, p=0.001);. No significant correlation was found between BASDAI and BAQ insert ignore into journalissuearticles values(p=0.167);. The results of the simple linear regression analysis suggested that CSI-A explained 17.2% of the disease activity. BASDAI insert ignore into journalissuearticles values(β = 0.415, p=0.001); significantly predicted central sensitization. BASDAI was strongly correlated with VAS insert ignore into journalissuearticles values(r=0.665, R2= 0.442, p<0.001);. The VAS explained 44.2% of the disease activity, and BASDAI insert ignore into journalissuearticles values(r=0.665, p<0.001); significantly predicted pain severity. Conclusion: High disease activity adversely affects central sensitization and body awareness in patients with axSpA. Physicians should also consider a multimodal biopsychosocial perspective in the management of patients with high disease activity.
Keywords : Central sensitization, spondyloarthritis, awareness, pain