Immature ganulocytes are a potential biomarker in the early diagnosis of lower extremity subacute arterial thrombosis

Authors : Güler Gülsen Ersoy, Sedat Gülten, Burak Tamtekin

Pages : 498-501

Doi:10.32322/jhsm.1631350

View : 46 | Download : 37

Publication Date : 2025-05-30

Article Type : Research Paper

Abstract :Aims: Acute arterial embolism in peripheral arteries is generally diagnosed quickly. In contrast, subacute arterial thrombosis (SAT), which arises as an acute exacerbation of chronic peripheral artery disease (PAD), is often more challenging to diagnose rapidly, primarily due to the development of collateral circulation. This study aims to investigate the role of immature granulocytes (IG) in the early diagnosis of SAT in patients with chronic PAD. Methods: This retrospective study was conducted at a single center between 2019 and 2021. A total of 99 patients with chronic lower extremity PAD were included in the study. Of these, 27 patients (27.2%) who developed exacerbations in the form of SAT were assigned to the SAT group. The remaining 72 patients (72.8%) with chronic PAD were included in the control group. Blood samples from patients in both groups were collected at their first admission before receiving any treatment. Complete blood count parameters were analyzed using an automatic hematological analyzer and compared between the two groups. Results: Comparison between the control and SAT groups revealed significant differences in hemogram parameters. These parameters included white blood cell count (WBC, p<0.001), neutrophil count (NEUT#, p<0.001), lymphocyte count (LYMPH#, p=0.004), eosinophil count (EO#, p=0.035), neutrophil percentage (NEUT%, p<0.001), lymphocyte percentage (LYMPH%, p<0.001), monocyte percentage (MONO%, p=0.013), eosinophil percentage (EO%, p=0.008), immature granulocyte count (IG#, p<0.001), immature granulocyte percentage (IG%, p=0.002), neutrophil-to-lymphocyte ratio (NLR, p<0.001). These parameters were statistically significantly different in patients with SAT compared to patients with chronic atherosclerotic lower extremity peripheral artery. Conclusion: Our study demonstrates that immature granulocytes show 81% sensitivity and %59 specificity for the early diagnosis of SAT. These findings suggest that immature granulocytes may serve as a reliable biomarker for the early detection of SAT.
Keywords : Periferik arter hastalığı, tanı, immatür granülositler.

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