The effect of obesity on prognosis in patients with endometrioid type endometrial adenocarcinoma

Authors : Özcan Gül, Guzin Demirağ

Pages : 383-388

Doi:10.32322/jhsm.1658483

View : 95 | Download : 63

Publication Date : 2025-05-30

Article Type : Research Paper

Abstract :Aims: This study sought to investigate the relationship between pre-treatment body-mass index (BMI) and established prognostic factors associated with endometrial cancer, as well as to assess its impact on survival in patients diagnosed with this malignancy. Methods: Patients diagnosed with endometrioid-type endometrial cancer between January 2000 and June 2010 at the medical oncology clinic, and who received treatment and follow-up at our clinic, were included in the study. The patient files and the hospital electronic database were retrospectively reviewed. The patients were divided into non-obese (BMI <30 kg/m2) and obese (BMI ≥30 kg/m2) groups, then compared in terms of clinical characteristics, pathological results, and survival outcomes. Results: A total of 126 patients, 44 in the non-obese group and 82 in the obese group, were included in the study. The two groups were statistically similar when classified according to demographic and clinicopathological data. Stage, tumour grade, cytology, depth of myometrial or lymphovascular invasion and lymph node metastasis were significantly associated with 5-year survival. The 5-year disease-free survival rate was 86.4% in the non-obese group and 87.8% in the obese group. When examining cause-specific survival rates, they were found to be 86.4% and 90.2%, respectively and no statistically significant association was observed between 5-years survival outcomes between both groups. Conclusion: This study demonstrated that there was no significant relationship between obesity and the defined prognostic factors of the disease and 5-year survival results.
Keywords : endometrial kanser, obezite, sağkalım

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