Role of anticardiolipin antibodies in bad obstetric history detected by ELISA test in a tertiary care centre

Authors : Therese Mary DHASON

Pages : 43-47

Doi:10.5455/jicm.24.259659

View : 23 | Download : 14

Publication Date : 2017-06-30

Article Type : Research Paper

Abstract :Background: Antiphospholipid syndrome insert ignore into journalissuearticles values(APS); is one of the causes of recurrent abortions and intrauterine death among pregnant women. This study was undertaken to find out the association between bad obstetric history insert ignore into journalissuearticles values(BOH); and anticardiolipin insert ignore into journalissuearticles values(aCL); antibody. Material and Methods: Blood samples were collected from women with BOH referred insert ignore into journalissuearticles values(recurrent abortion, intrauterine death, PIH); to a Tertiary Care Center in Chennai, Tamil Nadu. Blood samples from 100 pregnant women with BOH and 110 healthy pregnant women were collected and tested for the presence of  aCL antibody by ELISA Method. Results: Among the 100 patients tested 21 insert ignore into journalissuearticles values(21%); were aCL  positive; IgG was positive in 16 insert ignore into journalissuearticles values(76.19%); patients and IgM was positive in 5insert ignore into journalissuearticles values(23.80%); patients. Anticordiolipin antibody insert ignore into journalissuearticles values(aCL); positivity in BOH was statistically significant insert ignore into journalissuearticles values(p .0048); when compared to healthy pregnant women. There was a positive correlation insert ignore into journalissuearticles values(p 0.005); between IgG and BOH. The antibody titer was high in 12 insert ignore into journalissuearticles values(57.14%); and moderate in 6 insert ignore into journalissuearticles values(28.57%);. Among the controls 8insert ignore into journalissuearticles values(7.2%); were aCL  positive. Conclusion: Screening of patients with BOH for aCL by ELISA will reduce foetal morbidity and mortality as there is a significant association between high, moderate titers of aCL, insert ignore into journalissuearticles values(IgG); and BOH.
Keywords : Antiphospholipid syndrome, Anticordiolipin Elisa, Bad Obstetric History