High Eosinophilia Strongly Associated with Human Toxocariasis

Authors : Ayşegül AKSOY GÖKMEN, Aylin BABAOĞLU, Bayram Pektaş PEKTAŞ, Selçuk KAYA, Derya DİRİM ERDOĞAN, Metin KORKMAZ

Pages : 84-90

View : 14 | Download : 9

Publication Date : 2019-09-30

Article Type : Research Paper

Abstract :Backround:  The aim of this study was to reveal the prevalence of toxocariasis in patients with eosinophilia using Western blotting, and to show the importance of eosinophilia for toxocariasis.  Materials and Methods:  For this aim, 122 individuals, of whom 37 was without eosinophilia, were included to the study and in their serum sample, presence of IgG against Toxocara canis was investigated by Western blotting. Patients with eosinophilia were divided into two groups. In the first group insert ignore into journalissuearticles values(n=52);, eosinophilic cells constitute 3% to 10% of total white cells insert ignore into journalissuearticles values(<10% ); whereas in the second group insert ignore into journalissuearticles values(n: 33); eosinophilic cells constitute greater  than or equal to 10% of total white cells insert ignore into journalissuearticles values( ≥ 10%); . In addition, the cut-off value of the control group insert ignore into journalissuearticles values(n=37); for eosinophilia was ≤3% of total white cells. Results:  According to the results that obtained from the study, 62.3% insert ignore into journalissuearticles values(n=76/122); of all patients insert ignore into journalissuearticles values(including healthy people); were found seropositive. Also, 97% of insert ignore into journalissuearticles values(n=32/33); patient serum samples with ≥10 eosinophilia and 46.1% insert ignore into journalissuearticles values(n=24/52); of patient serum samples with <10% eosinophilia were found to be positive when patients were categorized depending on eosinophilia levels. Among control group serum samples with ≤3% eosinophilia insert ignore into journalissuearticles values(n=37);, 54% of them were detected to be positive. Conclusion:  Accordingly, the seropositivity rate detected in patients with at least 10% eosinophilia was statistically significant when compared with the other groups insert ignore into journalissuearticles values( P<0.05 );. Seropositivity values detected in patients with eosinophilia are notable. Therefore, physicians should keep Toxocara spp. infection in mind in patients with eosinophilia. 
Keywords : Toxocara spp, human toxocariasis