In Silico, In Vitro Studies on Liposomal Cosmetic Formulations Used to Prevent the Development of Atopic Dermatitis in Children

Authors : Hatice Albayrak, Nurcihan Aslan

Pages : 129-137

Doi:10.58854/jicm.1830496

View : 75 | Download : 311

Publication Date : 2025-12-31

Article Type : Research Paper

Abstract :Objective:
Atopic dermatitis (AD) is a chronic inflammatory skin disease with high prevalence in childhood. The limited dermal penetration of current topical therapies highlights the need for more efficient and safer delivery systems. This study aims to develop and evaluate liposomal formulations for pediatric AD treatment using in silico and in vitro methodologies. Material and Methods: :
Formulation components were optimized, and various lipid ratios were analyzed through in silico stability and interaction modeling. Selected formulations were then prepared in the laboratory and evaluated through measurements of density, pH, viscosity, surface tension, and electrical conductivity. All analyses were performed in triplicate using calibrated instruments. The formulation was designed to minimize irritation and comply with clean-label principles. Results:
The developed liposomal formulations demonstrated stable physical characteristics, acceptable viscosity properties, and an optimal pH profile. The liposomal structure exhibited strong potential for enhancing dermal penetration of active compounds while reducing irritation risk. A strong consistency was observed between theoretical predictions and experimental findings. Conclusions:
This study demonstrates that liposomal formulations present an effective and safe alternative for the management of atopic dermatitis, particularly in pediatric patients. Their ability to enhance dermal penetration and reduce adverse effects suggests promising applicability in future nanopharmaceutical strategies. The environmentally conscious and clean-content design further supports their potential in modern dermatological therapeutics.
Keywords : Çocuklarda atopik dermatit, Lipozomal taşıyıcı sistemler, in silico, in vitro, Transdermal penetrasyon

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