Antimicrobial Efficacy of Silymarin and Silibinin Against Oral Microorganisms

Authors : Murali Iyangar Radhika, Devaraj Ezhilarasan, Prakasam Gopinath

Pages : 139-143

Doi:10.5799/jmid.367545

View : 12 | Download : 4

Publication Date : 2017-09-15

Article Type : Research Paper

Abstract :Objective: To evaluate the antimicrobial effect of silymarin and silibinin, a plant derived flavonoid compounds against oral microorganisms that are responsible for dental caries. Methods: In the current investigation, we analyzed the comparative antibacterial and antifungal effect of silibinin and silymarin against clinical cariogenic oral pathogens through evaluating their minimum inhibitory and minimum bactericidal concentration. We used clinical isolates that are responsible for dental caries and these include Candida albicans, Enterococcus faecalis, Lactobacillus acidophilus, Staphylococcus aureus and Streptococcus mutans to evaluate the anticariogenic potential of silymarin and silibinin. Results: In the present investigation, silymarin exhibit good antimicrobial effect against most of the oral cariogenic microorganisms tested when compared to silibinin. Interestingly, silymarin shows high sensitivity at a concentration of <5 µg/ml against S. mutans, L. acidophilus and C. albicans . On the other hand, silibinin also have significant antimicrobial effect against the oral pathogens.   Conclusions: Silymarin and silibinin can be used as appropriate drug candidates that control dental caries, endodontic infections. 
Keywords : Silibinin, Silymarin, Oral infections, Oral pathogens