Epidemiology and Antimicrobial Susceptibility of Anaerobic Bloodstream Infections: A 10 Years Study

Authors : Nadeem Sajjad RAJA

Pages : 135-139

Doi:10.5799/jmid.493845

View : 10 | Download : 4

Publication Date : 2018-12-15

Article Type : Research Paper

Abstract :Objective: The majority of patients with anaerobic bloodstream infections insert ignore into journalissuearticles values(BSIs); do not receive appropriate empirical antimicrobial treatment as this infection remains unsuspected on clinical basis. This study determines the incidence rate, the prevalence and antibiotic susceptibility pattern of anaerobes causing BSIs in East Sussex Healthcare Trust, England. Methods: It is a retrospective study from July 2007 to July 2017. Demographic and laboratory data were collected on all microbiologically proven anaerobic BSIs. Results: During the study period, 106,905 blood cultures were processed in the laboratory. A total of 324 anaerobic organisms were isolated from 312 blood cultures on 310 patients insert ignore into journalissuearticles values(167 males);, representing a positivity rate of 0.30% of total blood cultures and 2.41% of total positive blood cultures insert ignore into journalissuearticles values(13,425);. Approximately 76% insert ignore into journalissuearticles values(238 episodes); of anaerobic bacteremia occurred in >60 years old insert ignore into journalissuearticles values(236); patients. The admitting services were: emergency department insert ignore into journalissuearticles values(ED); insert ignore into journalissuearticles values(42%);, medical insert ignore into journalissuearticles values(25%);, surgical insert ignore into journalissuearticles values(16%); critical care unit insert ignore into journalissuearticles values(7%);, and hematology insert ignore into journalissuearticles values(5%);. The most frequent isolates were Bacteroides spp. insert ignore into journalissuearticles values(42%);, Clostridium spp. insert ignore into journalissuearticles values(24%);, and Propionibacterium spp. insert ignore into journalissuearticles values(9%);.  Polymicrobial bloodstream infections were recorded in 45 episodes. Amoxicillin/clavulanic acid, metronidazole, clindamycin remained most effective antibiotics against anaerobes with a sensitivity rate of 93%, 92%, and 81% respectively. Penicillin was least sensitive insert ignore into journalissuearticles values(43%); against anaerobes. Conclusions: This study highlights a low rate of anaerobic bacteremia during 10 years with Bacteroides spp. as the predominant organism. This study also confirms that the empirical antibiotic therapy used in our hospital remains appropriate as more than 92% isolates were sensitive to amoxicillin/clavulanic acid and metronidazole. J Microbiol Infect Dis 2018; 8insert ignore into journalissuearticles values(4);: 135-139
Keywords : Anaerobes, antibiotics, bloodstream infections, susceptibility