Predictors of Urinary Tract Infection and Their Diagnostic Performances among Cameroonian Under-five

Authors : Dorgelesse Francine Kouemo MOTSE, Guy Pascal NGABA, Loick Pradel KOJOM, Danielle Christiane Kedy KOUM, Cecile Ebongue OKALLA, Calixte İda PENDA, Evelyn MAH, Andreas CHİABİ, Dieudonné Désiré ADİOGO

Pages : 68-77

Doi:10.5799/jmid.574542

View : 9 | Download : 4

Publication Date : 2019-06-15

Article Type : Research Paper

Abstract :ABSTRACT Objective: Urinary tract infection insert ignore into journalissuearticles values(UTIs); in child is serious public health problem especially in developing countries. This aimed at identifying factors associated with urinary tract infection and determining their diagnosis performances as well as resulting algorithms among Cameroonian under-five. Methods: A descriptive and analytical cross sectional study took place from May 2013 to March 2014 at Pediatrics Department of the Bonassama District hospital in the town of Douala. Urine samples were collected dependent on the age of children and its aptitude to micturate. Ten microliters insert ignore into journalissuearticles values(10 µL); of urine specimen were cultured at 37°C for 24-48 hours. In addition, sociodemographic, anthropometric, clinic and biological information of each child were documented. Results: The prevalence of UTI was 32.2% insert ignore into journalissuearticles values(129/400); which was mainly caused by Escherichia coli insert ignore into journalissuearticles values(41.1%);. A total of four risk factors for UTI were found after adjustment for all pertinent characteristics of children. These included female gender insert ignore into journalissuearticles values(ARR= 0.55; p= 0.0046);, presence of fever insert ignore into journalissuearticles values(ARR = 1.83; p= 0.0426);, trouble urine insert ignore into journalissuearticles values(ARR = 1.36; p= 0.0063); and presence of nitrites in urine insert ignore into journalissuearticles values(ARR = 1.09; p= 0.0001);. Presence of nitrites was the most discriminant parameter based on specificity insert ignore into journalissuearticles values(98.1%);, positive predictive value insert ignore into journalissuearticles values(95.4%); and negative predictive value insert ignore into journalissuearticles values(90.1%);. The diagnosis performances have gradually improved with the increasing number of parameters.  Conclusion: This study reported four factors associated with increased risk for UTI. This also outlined that the presence of nitrites in urine had best diagnosis performances and different predictors-based clinical algorithms could be helpful especially in the identification of UTI-negative children.   J Microbiol Infect Dis 2019; 9insert ignore into journalissuearticles values(2);:68-77.
Keywords : Under five, urinary tract infection, predictors, predictive potential, Cameroon