Trichosporon Asahii Infection Mortality in Pediatric Oncology Patients: A Report of Six Cases

Authors : Adil Abdelhamed ABBAS, Abdulfattah Wasel ALAMRİ, Areej Hassan ALMOFTİ

Pages : 167-172

Doi:10.5799/jmid.790293

View : 15 | Download : 3

Publication Date : 2020-09-15

Article Type : Other Papers

Abstract :The frequency of invasive fungal infections in patients with hematological malignancies has dramatically increased over the last two decades mainly due to increased use of more intensive therapies. Trichosporon spp is an uncommon but frequently fatal invasive yeast infection that occur predominantly in patients with hematological malignancies. Trichosporon Asahii insert ignore into journalissuearticles values(T. Asahii); is the most common genus isolated and is reported to cause serious invasive infections in adults and infrequently in children. Voriconazole insert ignore into journalissuearticles values(VCZ); remains the antifungal drug of choice. We report six pediatric patients with acute lymphoblastic leukemia insert ignore into journalissuearticles values(2);, acute myeloblastic leukemia insert ignore into journalissuearticles values(2);, lymphoblastic lymphoma insert ignore into journalissuearticles values(1); who developed invasive T. Asahii infection during the early phases of CTR. The outcome was poor. Five patients have died as a result of the infection after a stormy clinical course and prolonged stay in the pediatric intensive care unit despite receiving proper antifungal treatment. Only one patient survived the infection without serious sequalae. J Microbiol Infect Dis 2020; 8insert ignore into journalissuearticles values(3);:167-172.
Keywords : Amphotericin B, Caspofungin, Invasive fungal infections, Trichosporon Asahii, Voriconazole