Association of Clostridioides difficile infection with specific malignant conditions

Authors : Chetana VAISHNAVI, Megha SHARMA, Pramod GUPTA, Rakesh KOCHHAR

Pages : 124-131

Doi:10.5799/jmid.993843

View : 10 | Download : 4

Publication Date : 2021-09-15

Article Type : Research Paper

Abstract :Objectives: Patients with concomitant diseases, particularly malignancies, are at significant risk for Clostridioides difficile infection insert ignore into journalissuearticles values(CDI);. However, very little is known about the association between malignancy and CDI. Therefore, we evaluated the association of CDI in patients with different kinds of malignancies compared to control patients. Methods: Patients insert ignore into journalissuearticles values(n=1022); with specific malignancies insert ignore into journalissuearticles values(496 patients, 328 men);, subgrouped as Adenocarcinoma insert ignore into journalissuearticles values(AC);, Hematological malignancies insert ignore into journalissuearticles values(HM);, Multiple myeloma insert ignore into journalissuearticles values(MM);, Pediatric solid tumor insert ignore into journalissuearticles values(PST);, and controls insert ignore into journalissuearticles values(526 controls, 325 men); without any specific diseases were enrolled in the study. Laboratory data of the patients were reviewed for demographics, antibiotic exposure, clinical symptoms, and fecal Clostridioides difficile toxin insert ignore into journalissuearticles values(CDT); assay. Results: Of 1022 patients, 805 received antibiotics. CDT was positive in 168 insert ignore into journalissuearticles values(80.0%); of those receiving antibiotics and in 42 insert ignore into journalissuearticles values(20.0%); not receiving antibiotics insert ignore into journalissuearticles values(p 0.05);. Correlation of different malignant conditions with control and among themselves showed male gender in AC insert ignore into journalissuearticles values(p=0.039); and HM insert ignore into journalissuearticles values(p=0.003);, antibiotic exposure in MM insert ignore into journalissuearticles values(p<0.001); and fever in PST and HM subgroups to be significant insert ignore into journalissuearticles values(p<0.001);. Conclusion: CDT positivity was higher in males and patients exposed to antibiotics. No significant association of CDT was seen in malignant patients compared to the controls, though patients in PST and AC subgroups were more prone to CDI. J Microbiol Infect Dis 2021; 11insert ignore into journalissuearticles values(3);:124-131.
Keywords : Clostridioides difficile infection, Hematologic malignancy, Adenocarcinoma, Multiple myeloma, Pediatric solid tumor