Vertical Virus Transmission from SARS-CoV-2-positive Mothers to Neonates: A Tertiary Care Hospital Experience

Authors : Neha SİNGH, Nikita SHERWANİ, Jyoti JAİSWAL, Tripti NAGARİA, Arvind NERAL, Onkar KHANDWAL

Pages : 1-5

Doi:10.5799/jmid.1085903

View : 10 | Download : 2

Publication Date : 2022-03-15

Article Type : Research Paper

Abstract :ABSTRACT Objectives: The coronavirus disease 2019 insert ignore into journalissuearticles values(COVID-19); outbreak is evolving rapidly worldwide. However, little is known about the association between pregnant women with COVID-19 and its transmission to neonates. This investigation aimed to see if COVID-19 infection could be transmitted vertically into the uterus. Methods: We conducted a prospective observational study. 48 COVID-19 infected mothers were enrolled during their third trimester. A qRT-PCR assay of the nasal and oropharyngeal swab samples was performed to confirm positive for COVID-19 infection as per WHO protocol. In addition, characteristics of pregnant women with confirmed SARS -CoV-2 infection and newborns were documented. Results: Forty-eight expectant mothers, 10 insert ignore into journalissuearticles values(20.8%); were found symptomatic, and 38 insert ignore into journalissuearticles values(79.2%); were asymptomatic, with COVID-19 infection were delivered insert ignore into journalissuearticles values(33 cesarean section & 15 vaginal deliveries);. One female child insert ignore into journalissuearticles values(4.1%); out of 48 newborns was initially diagnosed with COVID-19 infection based on a nucleic acid qRT-PCR. The female child showed no or negligible signs and recovered completely, whereas 47 neonates insert ignore into journalissuearticles values(95.9%); confirmed negative. None of the mothers or neonates died from COVID-19 related pulmonary problems. Conclusion: There is insufficient evidence on vertical virologic transmission of COVID-19 infection during the third trimester of pregnancy. Additionally, research and surveillance involving adequate testing of samples of placental tissue, breast milk, vaginal swab, amniotic fluid, and cord blood will be needed to establish the possibility of vertical transmission of infection. J Microbiol Infect Dis 2022; 12insert ignore into journalissuearticles values(1);:1-5.
Keywords : Coronavirus, COVID 19, Neonate, Pregnant mothers, SARS CoV 2, Vertical transmission